ID   A0A2S6CTB4_9CYAN        Unreviewed;       336 AA.
AC   A0A2S6CTB4;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=adenosine deaminase {ECO:0000256|ARBA:ARBA00012784};
DE            EC=3.5.4.4 {ECO:0000256|ARBA:ARBA00012784};
GN   ORFNames=CUN59_12350 {ECO:0000313|EMBL:PPJ63015.1};
OS   Cuspidothrix issatschenkoi CHARLIE-1.
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Aphanizomenonaceae;
OC   Cuspidothrix.
OX   NCBI_TaxID=2052836 {ECO:0000313|EMBL:PPJ63015.1, ECO:0000313|Proteomes:UP000239589};
RN   [1] {ECO:0000313|EMBL:PPJ63015.1, ECO:0000313|Proteomes:UP000239589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHARLIE-1 {ECO:0000313|EMBL:PPJ63015.1,
RC   ECO:0000313|Proteomes:UP000239589};
RA   Kust A., Mares J., Jokela J., Urajova P., Hajek J., Saurav K., Voracova K.,
RA   Fewer D.P., Haapaniemi E., Permi P., Rehakova K., Sivonen K., Hrouzek P.;
RT   "Discovery of a pederin family compound in a non-symbiotic bloom-forming
RT   cyanobacterium.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PPJ63015.1}.
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DR   EMBL; PGEM01000083; PPJ63015.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S6CTB4; -.
DR   OrthoDB; 105475at2; -.
DR   Proteomes; UP000239589; Unassembled WGS sequence.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:UniProt.
DR   CDD; cd00443; ADA_AMPD; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR   PANTHER; PTHR11409:SF43; ADENOSINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000239589}.
FT   DOMAIN          5..320
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   336 AA;  39118 MW;  3120C6BD45360EE9 CRC64;
     MALYAELHRH LGGSVVPRVL WRYFQRHNTE LISPFAEYPE FEDFYTRPRN TLDEYLELHT
     LVESVQTVET LPYFIYRLLR GAYIFENLAY LELRYTPYLR TPEHLNQNER IDKMAEIVDI
     VGKASCSLEY PIVTSQILCM HSRLPFEVNK AIIDLAAQNR KYVCAIDVAG GDRYYAERME
     EWISLYNYAH SLGINTTGHL YETKDGCYPE LLPYLMRIGH GIQIPILYPE LLPEIARRGQ
     CLEVCPTTYL KTGTLQDIRQ LKLVFDRCFE TGVDIAICTD NAGLHNMRLP FEYENLLTYD
     IINFQQLQAC QDAAFRHAFA WPHSQRPASL LTALLK
//