ID A0A2S6FXY1_9CLOT Unreviewed; 786 AA.
AC A0A2S6FXY1;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Endonuclease MutS2 {ECO:0000256|HAMAP-Rule:MF_00092};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_00092};
GN Name=mutS2 {ECO:0000256|HAMAP-Rule:MF_00092};
GN ORFNames=BD821_10795 {ECO:0000313|EMBL:PPK48458.1};
OS Clostridium algidicarnis DSM 15099.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1121295 {ECO:0000313|EMBL:PPK48458.1, ECO:0000313|Proteomes:UP000239863};
RN [1] {ECO:0000313|EMBL:PPK48458.1, ECO:0000313|Proteomes:UP000239863}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15099 {ECO:0000313|EMBL:PPK48458.1,
RC ECO:0000313|Proteomes:UP000239863};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Endonuclease that is involved in the suppression of
CC homologous recombination and may therefore have a key role in the
CC control of bacterial genetic diversity. {ECO:0000256|HAMAP-
CC Rule:MF_00092}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00092}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_00092}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPK48458.1}.
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DR EMBL; PTIS01000007; PPK48458.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S6FXY1; -.
DR STRING; 37659.GCA_000703125_02337; -.
DR OrthoDB; 9808166at2; -.
DR Proteomes; UP000239863; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR CDD; cd03280; ABC_MutS2; 1.
DR Gene3D; 3.30.1370.110; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00092; MutS2; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR046893; MSSS.
DR InterPro; IPR005747; MutS2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002625; Smr_dom.
DR InterPro; IPR036063; Smr_dom_sf.
DR NCBIfam; TIGR01069; mutS2; 1.
DR PANTHER; PTHR48378; DNA MISMATCH REPAIR PROTEINS MUTS FAMILY DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR48378:SF2; SMR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF20297; MSSS; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF01713; Smr; 1.
DR PIRSF; PIRSF005814; MutS_YshD; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SMART; SM00463; SMR; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF160443; SMR domain-like; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR PROSITE; PS50828; SMR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00092}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00092};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|HAMAP-
KW Rule:MF_00092}; Hydrolase {ECO:0000256|HAMAP-Rule:MF_00092};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00092};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00092}.
FT DOMAIN 711..786
FT /note="Smr"
FT /evidence="ECO:0000259|PROSITE:PS50828"
FT COILED 523..620
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 332..339
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00092"
SQ SEQUENCE 786 AA; 88331 MW; 5512F24B86651FB0 CRC64;
MNNRALKILE FSKVKDEIKR YASTKAAKDI IDDLVPYTNV YEVNRSLKET EEALNSMVKK
GPPPFYGLYD VRDYLIRIEK GGGVLATNLL KIAQMLRCSR GIKDYVNRKV EEESFPMLEN
ICEGIVPLKY LEEEIFRIIV SDEEISDRAS DTLYTIRRSL KDKNSSLKDK VNSLIKTYSK
YLQENLYTVR GDRYVIPVKA EHKGMVPGLV HDQSSSGATL FIEPMGLVNL NNDIKELMLK
EEAEIERILD ELCFKIYEKI EVIKVNAQII WEIDFIFSKA KYASEINAIK PKVNEDGSFN
IIQGRHPLID PKVVVPSDIY LGKDFTSIVI TGPNTGGKTV TLKTVGLLHV MAMSGVMIPA
AYNSSINFFD EVFADIGDEQ SIEQSLSTFS SHMTNIVSII KEANKGSLVL LDELGAGTDP
TEGAALAMSI LEDLKSKDVK IIATTHYSEL KVYAINTKGV ENASVEFDVK TLRPTYRLLI
GIPGKSNAFE ISRKLGLPDY IIQSSKELIS KDSLEFEDLI ESLQSKSVDA DKFEREARLL
KEESEKLKEK YEQKLQALET SKEKILEESK RKAKIALKDA KEEADAILKN IRELEKMGYS
SKARQDIEEH RNKLAKELDK QSTTLIPKEH KGEKLVSVKL GEEVFVPSLN QNVIVLTNPD
NKGEVQVEAG IMKINLKLED LRKINNNKSS KERRNSKKQV NLNLKSVGAS VDLRGQDSEE
ACYNADKYLD EAYLGGLGLV SLIHGKGTGV LRKAINDMLK RHPHVKNFRL GEYGEGGDGV
TMVQLK
//
