ID A0A2S6G0L0_9CLOT Unreviewed; 976 AA.
AC A0A2S6G0L0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=BD821_101120 {ECO:0000313|EMBL:PPK49459.1};
OS Clostridium algidicarnis DSM 15099.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1121295 {ECO:0000313|EMBL:PPK49459.1, ECO:0000313|Proteomes:UP000239863};
RN [1] {ECO:0000313|EMBL:PPK49459.1, ECO:0000313|Proteomes:UP000239863}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15099 {ECO:0000313|EMBL:PPK49459.1,
RC ECO:0000313|Proteomes:UP000239863};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPK49459.1}.
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DR EMBL; PTIS01000001; PPK49459.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S6G0L0; -.
DR STRING; 37659.GCA_000703125_02838; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000239863; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 2.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 6.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 2.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:PPK49459.1};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 16..476
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT COILED 448..489
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 976 AA; 111340 MW; A8C4DB6B10C36B81 CRC64;
MAKKFIVPKD NNIIEVPLEE AMPENYLPYA VEVAKDRALP DVRDGLKPVH RRILYGAYLL
KAFPDKAYFK SARIVGDILG KFHPHGDTSV YDAMTILAQD FSTRYKLIDG HGNWGSMDGD
GAAAMRYTEA RLTPLALQMI RDIDKDVVDM ALNYSDTEFE PTVLPSRYPN LLVNGAFGIA
VGLATNIPPH NLKEVIDASI KLMEDENITT KELMEYIKGP DLPTGGIILG KESLLAAYET
GEGKVTSRAK TSIETLENGR FGIIITEFPY RKNKSKILQA ISDMTGDKKH AKYLESIVDI
RDESDRTGVR SVVELKKTVE YEDAEKVLKY LFKKTDLQCN INFNMVALAN GKPETLGLKS
ILKHYVNHQK EVVIRRTKRE LNIAEKRFHI VEGFIKAVGA MDEIISIIRA SKSKKDASNN
LIERFEFSKE QTEAILELML YRLTGLEIKV FEKEYKELSK VIKSLKNILE NEKELLKVIK
SELLEIRNTY GDERRTKIVE DDSEGKIDLE ELLVVEDIMV TLSKDGFIKR VPMKSYNRIN
SDISDIEYRE GDAGRFLFQS NTKDTILVFT NKGQMYQIRG NDLPERKWKD NGVRLDSLIR
SFNLDEETIV DVYSIENFSS SLDFMFLTSK GNIKKTSLDK FQTNYSRYSA LKLKKEDYLI
DVKLVKKDRE EGFINIITKK GLNFDLEEPK LEESDRNVLG QQLFLLCKED EIIKAEYCKE
MKYSEMIIGV NPQGNLKSFK KNSASTYKKV LTNSKEFIII FTDRGFAYKI PGFMIGNIED
STINIEDLVD TFLKGKEKVL NILSSKDFNE EIWMYFFTKR GMIKKTNIKE LKGEYIETQV
YKYKYEDDTL VTVEFGKDQN QEILLVTEKA MGIKFTSNSI KEMGKVASGV TGISLKEEDK
VVFGTLTENS DDSNSNLCYN KEIAFTTNIK SINLLSSSGR KEGVKLENIK LQNRAGRGNN
IMAISTGEYI KDIKLK
//
