ID A0A2S6GJ25_9PSEU Unreviewed; 500 AA.
AC A0A2S6GJ25;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=L-lactate dehydrogenase {ECO:0000313|EMBL:PPK65156.1};
GN ORFNames=CLV40_1153 {ECO:0000313|EMBL:PPK65156.1};
OS Actinokineospora auranticolor.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinokineospora.
OX NCBI_TaxID=155976 {ECO:0000313|EMBL:PPK65156.1, ECO:0000313|Proteomes:UP000239203};
RN [1] {ECO:0000313|EMBL:PPK65156.1, ECO:0000313|Proteomes:UP000239203}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YU 961-1 {ECO:0000313|EMBL:PPK65156.1,
RC ECO:0000313|Proteomes:UP000239203};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-lactate + NAD(+) = H(+) + NADH + pyruvate;
CC Xref=Rhea:RHEA:23444, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16651, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.27;
CC Evidence={ECO:0000256|ARBA:ARBA00001763};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPK65156.1}.
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DR EMBL; PTIX01000015; PPK65156.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S6GJ25; -.
DR Proteomes; UP000239203; Unassembled WGS sequence.
DR GO; GO:0004459; F:L-lactate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR CDD; cd00293; USP_Like; 1.
DR Gene3D; 3.40.50.12370; -; 1.
DR Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001557; L-lactate/malate_DH.
DR InterPro; IPR018177; L-lactate_DH_AS.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR001236; Lactate/malate_DH_N.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR43128; L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)); 1.
DR PANTHER; PTHR43128:SF16; L-LACTATE DEHYDROGENASE; 1.
DR Pfam; PF02866; Ldh_1_C; 1.
DR Pfam; PF00056; Ldh_1_N; 1.
DR Pfam; PF00582; Usp; 1.
DR PRINTS; PR00086; LLDHDRGNASE.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00064; L_LDH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000239203}.
FT DOMAIN 10..43
FT /note="UspA"
FT /evidence="ECO:0000259|Pfam:PF00582"
FT DOMAIN 187..325
FT /note="Lactate/malate dehydrogenase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00056"
FT DOMAIN 328..464
FT /note="Lactate/malate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02866"
FT REGION 93..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 500 AA; 51215 MW; 09DAD93999924CD4 CRC64;
MLLDAAPHAV TGHRGLGGVE GLLIGSVSDA VAAHARCPVV VVRGTAGPIV FGVDGSRAGG
AAIGFALEQA AGRGEEHAEV PVRLVVPRDR AARVDGAERG RPTPRRRGQG ARAAHRPGHG
LDRPCSAAPR RVPGGGRAHL TGPVTSGPVR HCGRLALRDT VQDPWSRSAA VSRLGGVTDR
RAARGPRIAV VGAGQVGSTL AYACQIRGTA NTVALFDTDA AKLRAQVLDL RHGGMFAPTV
EVVGSDDVGI CAGADVVVIT AGARQRAGES RMALAGRNVR LCRALVPELC ALAPEAVFLV
VTNPVDVVTQ AVLEVSGLPA HRVLGSGTVL DSSRLRALIA ARAGVGVAGV CAYIVGEHGD
TAVPLWSQAF IGSVPVLDWV VDGRQVFDEP ARREIEDSVV GAAYEVIAGK GATNYAVGLA
VTHVLEAILG DQRLILPVSA YVADFHGIGG VCLSLPRIVD RSGAGALEPT VPGTAELAGL
RRCAHVIAKA CRESGVDVCG
//
