ID   A0A2S6II17_9ACTN        Unreviewed;       391 AA.
AC   A0A2S6II17;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Threonine dehydrogenase-like Zn-dependent dehydrogenase {ECO:0000313|EMBL:PPK93826.1};
GN   ORFNames=CLV92_109103 {ECO:0000313|EMBL:PPK93826.1};
OS   Kineococcus xinjiangensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kineosporiales; Kineosporiaceae;
OC   Kineococcus.
OX   NCBI_TaxID=512762 {ECO:0000313|EMBL:PPK93826.1, ECO:0000313|Proteomes:UP000239485};
RN   [1] {ECO:0000313|EMBL:PPK93826.1, ECO:0000313|Proteomes:UP000239485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22857 {ECO:0000313|EMBL:PPK93826.1,
RC   ECO:0000313|Proteomes:UP000239485};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT   (KMG-II): from individual species to whole genera.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PPK93826.1}.
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DR   EMBL; PTJD01000009; PPK93826.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S6II17; -.
DR   OrthoDB; 241504at2; -.
DR   Proteomes; UP000239485; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08283; FDH_like_1; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR42813:SF2; DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000239485};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          26..141
FT                   /note="Alcohol dehydrogenase-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08240"
FT   DOMAIN          189..255
FT                   /note="Alcohol dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00107"
SQ   SEQUENCE   391 AA;  42047 MW;  1EB2953344A57D20 CRC64;
     MKAVTWQGTR SMSVQEVPDP VLQEPTDAIV RITSTAICGS DLHLYEVLGP FMTKGDVVGH
     EPMGVVEAVG AGVTNLQVGD RVVLPFQISC GRCFMCSRNL QTQCETTQVR EYGSGAALYG
     YSKLYGEVPG GQAELLRVPY ADYNPIKVGT ELPDERYLFL SDILPTAWQG VAYADVPEGG
     TLAVLGLGPV GQFAARIGRH LGHRVIAVEP VPERRAMAQR YGVEVLDLTD DVADRLRELT
     DGRGPDAVVD AVGMEAHGSG AGKFAQKAAS LLPDAIARKA FTTAGVDRLT ALHTALDAVR
     RGGTVSLSGV YGGEADPMPM LSMFDKQLQL RMGQCNVKSW IDDLLPLVED PADPLGVLDL
     TTHRVPLDEA PAMYELFQKK EDGCIKVVLQ P
//