ID A0A2S7JZG5_9PROT Unreviewed; 646 AA.
AC A0A2S7JZG5;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Sodium:proton exchanger {ECO:0000313|EMBL:PQA85588.1};
GN ORFNames=CW354_21875 {ECO:0000313|EMBL:PQA85588.1};
OS Marinicaulis flavus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Parvularculales;
OC Parvularculaceae; Marinicaulis.
OX NCBI_TaxID=2058213 {ECO:0000313|EMBL:PQA85588.1, ECO:0000313|Proteomes:UP000239504};
RN [1] {ECO:0000313|EMBL:PQA85588.1, ECO:0000313|Proteomes:UP000239504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SY-3-19 {ECO:0000313|EMBL:PQA85588.1,
RC ECO:0000313|Proteomes:UP000239504};
RA Hurst M.R.H.;
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PQA85588.1}.
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DR EMBL; PJCH01000017; PQA85588.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S7JZG5; -.
DR OrthoDB; 570124at2; -.
DR Proteomes; UP000239504; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR PANTHER; PTHR32507:SF0; NA(+)_H(+) ANTIPORTER 2-RELATED; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000239504};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..399
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 411..516
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02254"
FT REGION 600..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..633
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 646 AA; 69595 MW; 443CC6599D518D9D CRC64;
MENLVLAFAI IGVLGIGAQW LAWRFNLPAI VLMAVAGILA GPVFNIFSAS DAPPGTPPME
ALFGDFYRPI IAVAVAVILF EGGLQLNFSE LRGLTRGVRR LVLPGVPIAW FLAAIAGYLI
AGLTWQAALL FGGIMVVTGP TVIIPLLRQS RLNARPATLL KWEGIVNDPI GALLAVLVYE
FLVIGDHSGT SIEIVSSLVL AALLSAGLGF AFGRFTATSF RRGWVPEYLK PPVLLALVLV
CFELANLMQE EAGLLSVTAM GVTLANSRIA SIDDLRLFKE NITVMLVSGV FIILTANLTM
GDIAALDWRS FWFIIAMLFV VRPLTVLIAT VGAGLPWKER LLVGWIAPRG IVAVAVTGFF
GASMTDAGYL DGDKVIALAF AMVFATVALH GFSISPLAKA LGLASRESPG VLIIGASPFA
ISLATKLKEM EIPVMVADTS WRRLKPARLA NVETYYGEIL SEVTEHHLDL NRFGYLLALG
GNEAHNALVA TDLAPELGRA AIFQVNARGK DEEDRKALSY TLQGRTFLQS GPALDELVRR
HYSGWIFQRT KLSDEYPPEQ YKKDLGAEGE LVLVIRKGVI NFASPEVPVT PETGDIALAY
IPKPSEPKEK PAKQDKEKEA KAEKDKETAP DKPADEPPAP PADDVV
//
