ID   A0A2S7K4L7_9PROT        Unreviewed;       681 AA.
AC   A0A2S7K4L7;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Squalene--hopene cyclase {ECO:0000313|EMBL:PQA87439.1};
GN   Name=shc {ECO:0000313|EMBL:PQA87439.1};
GN   ORFNames=CW354_11580 {ECO:0000313|EMBL:PQA87439.1};
OS   Marinicaulis flavus.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Parvularculales;
OC   Parvularculaceae; Marinicaulis.
OX   NCBI_TaxID=2058213 {ECO:0000313|EMBL:PQA87439.1, ECO:0000313|Proteomes:UP000239504};
RN   [1] {ECO:0000313|EMBL:PQA87439.1, ECO:0000313|Proteomes:UP000239504}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SY-3-19 {ECO:0000313|EMBL:PQA87439.1,
RC   ECO:0000313|Proteomes:UP000239504};
RA   Hurst M.R.H.;
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004999}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PQA87439.1}.
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DR   EMBL; PJCH01000007; PQA87439.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S7K4L7; -.
DR   OrthoDB; 9758578at2; -.
DR   UniPathway; UPA00337; -.
DR   Proteomes; UP000239504; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   InterPro; IPR006400; Hopene-cyclase.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01507; hopene_cyclase; 1.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000239504};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          23..315
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          329..628
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
SQ   SEQUENCE   681 AA;  77110 MW;  781247136141AA3D CRC64;
     MFDEKEAGAD KRSNFDRQLT ASIEAAADWL APRQKPEGYW VGRLESNACM EAQWILALWF
     MELEDHHLRP RLAASLRETQ RQDGSWEIYY GAPAGDINTT VEAYAALRSM GDDKDAAHMV
     RAREWILSKG GLKNIRVFTR YWLALIGEWP WKKTPNLPPE VIFFPNWFVF SIYNFAQWAR
     ATLMPIAVLS ARRPSRPLPA ERRLDELFPE GREKYNYAYP EKPGAGFAEA FFLTADKILH
     ALQSFGQTAG IGLLRKGAIS RALEWIIKHQ DADGVWGGIQ PPWIYSLMAL YNEGYAHDHS
     VVAKGLGALD DPRWRVDQGE ATWIQASTSP VWDTELTLLA LEDCDLSERH EKEVEKALDW
     LLSQQVLRKG DWSVKCPKLE PGGWAFEYKN YYYPDTDDTA VALIALAPFR NDPKWKDKGI
     EEAIEKGVEW LIGMQCKNGG WGAFDKDNDK QILTKIPFCD FGEALDPPSV DVTAHIIEAF
     GKLGIRKDHP VMLRALDYIK TEQEADGAWF GRWGVNYVYG TGAVLPALEA IGEDMTQHYI
     KKASDWLILH QNEDGGWGES CASYMDVKQM GRGKSTASQT AWALMGLAAV GRAEDERAIA
     DGVQFLIERQ KDGAWEEPEY TGTGFPGYGV GQHIKLTDPQ LQERLKQGPE LSRAFMINYN
     LYRHYFPMMA MGRVRKMMAG A
//