ID A0A2S7NMV8_9HELO Unreviewed; 350 AA.
AC A0A2S7NMV8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 13-SEP-2023, entry version 15.
DE RecName: Full=uroporphyrinogen decarboxylase {ECO:0000256|ARBA:ARBA00012288};
DE EC=4.1.1.37 {ECO:0000256|ARBA:ARBA00012288};
GN ORFNames=CJF30_00005519 {ECO:0000313|EMBL:PQE08639.1}, CJF30_00005865
GN {ECO:0000313|EMBL:PQE03362.1};
OS Rutstroemia sp. NJR-2017a BBW.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Rutstroemiaceae; Rutstroemia.
OX NCBI_TaxID=2070414 {ECO:0000313|EMBL:PQE03362.1, ECO:0000313|Proteomes:UP000238072};
RN [1] {ECO:0000313|EMBL:PQE03362.1, ECO:0000313|Proteomes:UP000238072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJR-2017a BBW {ECO:0000313|EMBL:PQE03362.1,
RC ECO:0000313|Proteomes:UP000238072};
RA Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
CC {ECO:0000256|ARBA:ARBA00004804}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen decarboxylase family.
CC {ECO:0000256|ARBA:ARBA00009935}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PQE03362.1}.
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DR EMBL; NJPT01000096; PQE03362.1; -; Genomic_DNA.
DR EMBL; NJPT01000072; PQE08639.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S7NMV8; -.
DR STRING; 2070414.A0A2S7NMV8; -.
DR UniPathway; UPA00251; UER00321.
DR Proteomes; UP000238072; Unassembled WGS sequence.
DR GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00717; URO-D; 1.
DR Gene3D; 3.20.20.210; -; 1.
DR InterPro; IPR038071; UROD/MetE-like_sf.
DR InterPro; IPR006361; Uroporphyrinogen_deCO2ase_HemE.
DR InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR NCBIfam; TIGR01464; hemE; 1.
DR PANTHER; PTHR21091; METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED; 1.
DR PANTHER; PTHR21091:SF169; UROPORPHYRINOGEN DECARBOXYLASE; 1.
DR Pfam; PF01208; URO-D; 1.
DR SUPFAM; SSF51726; UROD/MetE-like; 1.
DR PROSITE; PS00907; UROD_2; 1.
PE 3: Inferred from homology;
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000238072}.
FT DOMAIN 137..153
FT /note="Uroporphyrinogen decarboxylase (URO-D)"
FT /evidence="ECO:0000259|PROSITE:PS00907"
SQ SEQUENCE 350 AA; 39193 MW; FA6367B3E81B7DBB CRC64;
MGHQFEPLQN DLIIRTAWAG RYLPEYHEAK GNHDFFECCR SPEIASTLTL QPIERYAGLV
DAAIIFSDIL VIPQAMGMVV EMVDKKGPHF PSPLESPDDG QYEQVLNKKV DVAAELDYVY
KAITMTRHKL KGRVPLFGFC GAPWTLLCYM VEGGGSKLFV KTKTWVYKYS QASKDLLQKI
AEVCVEYLAL QVQAGAQLVQ VFDSWAAELS PSSFKEFSQP YLGYISANLP RRLKELGLEP
VPMVVFAKGA WYALDSLCDL GYQVVGLDWL QDPAEAVRIR GDRPIVFQGN ADPGVLYGTR
EAITRVVEEM VKGFGGGKQG WIANLGHGIT PFVNPDDLKF YFEEIHRLTK
//
