ID   A0A2S7PBA1_9HELO        Unreviewed;       602 AA.
AC   A0A2S7PBA1;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=2-hydroxyphytanoyl-lyase protein {ECO:0000313|EMBL:PQE11581.1};
GN   ORFNames=CJF32_00004753 {ECO:0000313|EMBL:PQE11581.1};
OS   Rutstroemia sp. NJR-2017a WRK4.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Rutstroemiaceae; Rutstroemia.
OX   NCBI_TaxID=2070412 {ECO:0000313|EMBL:PQE11581.1, ECO:0000313|Proteomes:UP000238813};
RN   [1] {ECO:0000313|EMBL:PQE11581.1, ECO:0000313|Proteomes:UP000238813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NJR-2017a WRK4 {ECO:0000313|EMBL:PQE11581.1,
RC   ECO:0000313|Proteomes:UP000238813};
RA   Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PQE11581.1}.
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DR   EMBL; NJPR01000123; PQE11581.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S7PBA1; -.
DR   STRING; 2070412.A0A2S7PBA1; -.
DR   InParanoid; A0A2S7PBA1; -.
DR   OrthoDB; 2020042at2759; -.
DR   Proteomes; UP000238813; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0004737; F:pyruvate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd02004; TPP_BZL_OCoD_HPCL; 1.
DR   CDD; cd07035; TPP_PYR_POX_like; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR045025; HACL1-like.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   PANTHER; PTHR43710; 2-HYDROXYACYL-COA LYASE; 1.
DR   PANTHER; PTHR43710:SF2; 2-HYDROXYACYL-COA LYASE 1; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:PQE11581.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000238813};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN          5..119
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          189..319
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          391..565
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
FT   REGION          580..602
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   602 AA;  63747 MW;  503FFABBE7364924 CRC64;
     MPSPTGAQLI AKALHELGVK VIFGLVGIPV VQIAEEAIAL GIRFIAFRNE QAASYAATAY
     GYLTGRPGVC LVVGGPGVLH AMAGVGNSSA NAFPMLLLAG SSETHLVTKG AFQELDAISL
     LAPHTKIAIR STLDSIAPSI TNAYRTSWYG RPGTGFVDLP ADVIQGEGEY IPTKMVSTAP
     KPAADPERIK AVTQLLKSAK APLIILGKGA AYAQAESLIR KLIDQTQIPF LPTPMGKGIL
     PDSHPLNTST ARSAALLGAD VILILGARLN WILHYGEAPK YNPSVKIIQV DISADEIGKN
     NGDASLGLVG DINIVTSQLL ASLQNWHYDT SSSPYIKTLQ ASTHKNEAKA ASAAQNAKIP
     LTYQHTFSLI KETIHSISPS SDGRVVYVSE GANTMDISRS AFPVSHPRLR LDAGTHATMG
     VGLGYAIAAH CAYNLPSPEA SSGPSLLGKK IVCLEGDSAL GFSLAEIETM ARYKMDILIF
     VLNNGGVYHG DSDSARTWRE LQGKSKDGSA KGGLRSTSLG WEVAYEKVAE MCGGRGYFVR
     TPEELRTATR EGFLATGEGP TVVNVVIEAG EGKALEFTWQ KSDSKKKDAN TKESTKKDVA
     KL
//