ID A0A2S7PLR7_9HELO Unreviewed; 1137 AA.
AC A0A2S7PLR7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Histone-lysine N-methyltransferase ASH1L protein {ECO:0000313|EMBL:PQE15221.1};
GN ORFNames=CJF32_00007843 {ECO:0000313|EMBL:PQE15221.1};
OS Rutstroemia sp. NJR-2017a WRK4.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Rutstroemiaceae; Rutstroemia.
OX NCBI_TaxID=2070412 {ECO:0000313|EMBL:PQE15221.1, ECO:0000313|Proteomes:UP000238813};
RN [1] {ECO:0000313|EMBL:PQE15221.1, ECO:0000313|Proteomes:UP000238813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJR-2017a WRK4 {ECO:0000313|EMBL:PQE15221.1,
RC ECO:0000313|Proteomes:UP000238813};
RA Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004448}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PQE15221.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NJPR01000114; PQE15221.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S7PLR7; -.
DR STRING; 2070412.A0A2S7PLR7; -.
DR InParanoid; A0A2S7PLR7; -.
DR OrthoDB; 950362at2759; -.
DR Proteomes; UP000238813; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR GO; GO:0015218; F:pyrimidine nucleotide transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR049562; SLC25A33/36-like.
DR PANTHER; PTHR45829; MITOCHONDRIAL CARRIER PROTEIN RIM2; 1.
DR PANTHER; PTHR45829:SF4; MITOCHONDRIAL CARRIER PROTEIN RIM2; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR Pfam; PF00856; SET; 1.
DR PRINTS; PR00926; MITOCARRIER.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:PQE15221.1};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000238813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:PQE15221.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 402..449
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 466..582
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 590..606
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REPEAT 806..917
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 927..1021
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 1043..1132
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 737..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 220..247
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 183..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..653
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1137 AA; 124707 MW; DE369DA819E86D4C CRC64;
MFSSLLDRMG ASSRASTKRE ITRAPSSDSL STAITVDDLS NAHSSSSTPP TSIGDDVSVS
SSSGKPEATT SDTVTVVEQP LKRSQRARAS VGTYNVKVLS GTAIHAPKKY LKNADGSDKA
SRRRTISGDT LVDALGSTNS STETFGKGAQ RLVSEGIDAL DLSWSVKKLP KSASQIGLVD
TPKKKFKQSE DPSRRKSLRS TGEKGEGLTK KLSVLGKRGR KNIEEGISKA TRELRNLADT
KEFAKIETEP VVFEVWSNGK LVPQEPARKK KKAEEVEAPA APPETKPEPE KKIAKGKKDK
FWLKRGIYAG QDPADLDWFK ASGNAKSQFV VDPDSKPRSI LPLPLWQGQR LLHVGRDFKL
PFDVCSPLPP GQPKPTEWFK TSSNRFIGEA ASMWKKSKLF DSFFSKCICK PETGCDEDCQ
NRIMLYECDD TNCGAGRDNC TNRAFAELQI RRKGDSTRKG GNKFDIGVEV FKTADRGYGV
RSNRCFNAQQ IIVEYTGEII TEDECDRRMN EDYKNNECYY LMSFDQNMII DATKGSIARF
VNHSCRPNCR MVKWIVEGKP RMALFAGDNP IMTGDELTYD YNFDPFSAKN VQECRCGSDN
CRGFLGPKPK NPTVTKSTTA IKDAVKAGLK AGKRKLQEMI GGDDDDGKDP RNPKKRRTKA
ATGAKRSASS TIKEVPKEAP KSTKETVTNR LLNARNAISS RKTVTFGQTA TTTTLKTYGK
KQMKLTTSNS TFTMVASTKN PRVKNEPVSP EKGSARSGRA SRHSTLSDDG NESTIRTPTA
SDSISRNGRT QTGYVSALAV KPAPVAKSWA HFVAGGVGGM TAAAVTAPLD VLKTRLQSDF
YQAQLAQSRL AKGILPHTHL SPLRSGLLHF RETFQILFSV HRIEGWRSLF KGLGPNLVGV
VPARSINFFV VGNGKRIIGD YTGAGPESAW VVCCAAALAG ITTSTVTNPI WLIKTRLQLD
KSVAERSGDV VKRRYKNSWD CIKQVVRGEG VRGLYKGMSA SYLGVTESTL QWVLFEQGKS
WMARRNQRIA LSKREKNIWD KTIDWTGTLF IAGGAKLVAA LGTYPHEVIR TRLRQAPSEN
GVPKYTGLVQ CAKLVFKEEG MVALYGGLTP HLLRTVPSAA IMFGMYEGIL KVLHAPA
//
