ID A0A2S7R054_9HELO Unreviewed; 572 AA.
AC A0A2S7R054;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=tyrosinase {ECO:0000256|ARBA:ARBA00011906};
DE EC=1.14.18.1 {ECO:0000256|ARBA:ARBA00011906};
GN ORFNames=CJF32_00009913 {ECO:0000313|EMBL:PQE32183.1};
OS Rutstroemia sp. NJR-2017a WRK4.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Rutstroemiaceae; Rutstroemia.
OX NCBI_TaxID=2070412 {ECO:0000313|EMBL:PQE32183.1, ECO:0000313|Proteomes:UP000238813};
RN [1] {ECO:0000313|EMBL:PQE32183.1, ECO:0000313|Proteomes:UP000238813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJR-2017a WRK4 {ECO:0000313|EMBL:PQE32183.1,
RC ECO:0000313|Proteomes:UP000238813};
RA Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone; Xref=Rhea:RHEA:34287,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57504,
CC ChEBI:CHEBI:57924; EC=1.14.18.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000426};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-tyrosine + O2 = H2O + L-dopaquinone; Xref=Rhea:RHEA:18117,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57924,
CC ChEBI:CHEBI:58315; EC=1.14.18.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001038};
CC -!- COFACTOR:
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000256|ARBA:ARBA00001973};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PQE32183.1}.
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DR EMBL; NJPR01000026; PQE32183.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S7R054; -.
DR STRING; 2070412.A0A2S7R054; -.
DR InParanoid; A0A2S7R054; -.
DR OrthoDB; 1908494at2759; -.
DR Proteomes; UP000238813; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004503; F:tyrosinase activity; IEA:UniProtKB-EC.
DR Gene3D; 2.60.310.20; -; 1.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR041640; Tyrosinase_C.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF32; TYROSINASE; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF18132; Tyosinase_C; 1.
DR Pfam; PF00264; Tyrosinase; 1.
DR PRINTS; PR00092; TYROSINASE.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR PROSITE; PS00498; TYROSINASE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000238813};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..572
FT /note="tyrosinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015704711"
FT DOMAIN 307..318
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00498"
SQ SEQUENCE 572 AA; 62389 MW; A746979A95683568 CRC64;
MAPILLKSLL ALSLASSAMG SPLDTRATTY AITGVQDSGV QARLEIRQLA ADPIQFNLFL
LAMMDFQAID QSKINSFYQI AGIHGYPLVP WDGVQGSGFN GYCTHGSNLF GPWHRPYLSV
FEQEIHKAGV AIAAKFPNNS VGQQYRAASL KLRIPYWDWA MNPTSGGILP SVYSNPTVAV
TFPNGTQATV PNPLASYKFH PLVPADLQNT TPFSSWDRTL RWPTSYDRAA TSQNDQAELQ
LEANQPNFRT QLMTLFSNYQ RYNTFSNEGS GSAGFGNLES IHDTVHVVTG GFNFAGHMTS
VPVAAFDPIF WGHHANIDRM LALWQAIYPD TYVDPTAQRG GTFTIASGST QTKSSPLTPF
HKDTKGTFFT SSDVRDTNTL GYSYPELINK PSNDTLKATI AALYAGSSPF GNQKRQAANN
TLARDYLVKV ELPWTAINGT YSVGVFLGKT EAAPADWAKD PKYVGMHATL GNRLDTAVDI
VATSNVHLTD ALLKKHSEGA LANLEEDTIV SYLTENLEWR VQKEGNEIPI ASLNGVKATA
QSIQNAAPSA PGTFANFRWV GDFKEYPGVF GN
//