ID   A0A2S7TK76_9FLAO        Unreviewed;       909 AA.
AC   A0A2S7TK76;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=oxoglutarate dehydrogenase (succinyl-transferring) {ECO:0000256|ARBA:ARBA00012280};
DE            EC=1.2.4.2 {ECO:0000256|ARBA:ARBA00012280};
GN   ORFNames=BSU00_05830 {ECO:0000313|EMBL:PQJ21982.1};
OS   Tenacibaculum sp. SG-28.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Tenacibaculum.
OX   NCBI_TaxID=754426 {ECO:0000313|EMBL:PQJ21982.1, ECO:0000313|Proteomes:UP000239112};
RN   [1] {ECO:0000313|Proteomes:UP000239112}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SG-28 {ECO:0000313|Proteomes:UP000239112};
RA   Kumagai Y., Yoshizawa S., Kogure K.;
RT   "Trade-off between light-utilization and light-protection in marine
RT   flavobacteria.";
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PQJ21982.1}.
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DR   EMBL; MQVY01000002; PQJ21982.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S7TK76; -.
DR   OrthoDB; 9759785at2; -.
DR   Proteomes; UP000239112; Unassembled WGS sequence.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   CDD; cd02016; TPP_E1_OGDC_like; 1.
DR   Gene3D; 3.40.50.12470; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR   Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR042179; KGD_C_sf.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR   PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR   PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000239112};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT   DOMAIN          575..768
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   909 AA;  103535 MW;  07F61E0D9485F3E9 CRC64;
     MDKFSFLNAV HAGFIGDLYE QYQNNPDAVE PSWRSFFQGY DLANEDYLLT DEEVSVEIPQ
     EVRKEFLVID LINGYRTRGH LFTKTNPVRE RRKYTPTLDI ENFGLSQSDL STVFNAGEIL
     GIGPKTLSQI IDHLKAIYCD SIGVEYMYLR NPEELKWWQN RLNENDNHPK YSADTKKYIL
     SKLNQAVGFE SFLQTKYVGQ KRFSVEGGET LIPGISIALR DAAEKYGVKE CVLGMAHRGR
     LNTLVNIFKK PVRDLFSEFE GKDFEDQAIA GDVKYHLGLT LSKQYKNGEE IKMNLVPNPS
     HLETVDAVVE GIVRAKVDND YEGDASKILP ILVHGDAAIA GQGIVYEVVQ MAQLNGYKTG
     GTIHVVVNNQ VGFTTNYLDA RSSTYCTDIA KVTLSPVLHV NADDAEAVCH AMQLAVEFRM
     KFKRDIFIDL LGYRKYGHNE GDEPRFTQPK LYKAIAKHKN PKLIYADALI AQNVVDASYV
     KQITDEFKEM LELEFQESKK QEVSRVNEFM PEVWTGFLRK KLETMLQPTD TTYSLSKLKN
     IAKVVSTVPE GVKFLRKAER ILNDRSKRVF ETNALDWGVA ETLAYGTLLE EGFDVRISGE
     DVERGTFSHR HAILRDEVSE ERINLLNTNK NNKGVMTIYN SHLSEYGVLG FDYGYAMAAP
     NTLTIWEAQF GDFANGAQIM FDQYISSAED KWKLQNGLVV LLPHGYEGQG PEHSSGRMER
     FLQSCAIDNM IVANCSTPAN MYHILRRQMK RDYRKPLIVF TPKSLLRLPK AVSTMEELAE
     GTFQEVIDDV SVTKSKVKKM VFCMGKFYYD LLEARESLGR EDVALVRIEQ LFPLHNEKIK
     EIMDLYPNVE RYVWAQEEPK NMGAWTHMLE RFENATLECA SRGYHSAPAA GSSARFKRRH
     QAVIDKVFD
//