ID A0A2S7U294_9BACT Unreviewed; 730 AA.
AC A0A2S7U294;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=BSZ32_09110 {ECO:0000313|EMBL:PQJ28647.1};
OS Rubritalea profundi.
OC Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC Rubritaleaceae; Rubritalea.
OX NCBI_TaxID=1658618 {ECO:0000313|EMBL:PQJ28647.1, ECO:0000313|Proteomes:UP000239907};
RN [1] {ECO:0000313|EMBL:PQJ28647.1, ECO:0000313|Proteomes:UP000239907}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SAORIC-165 {ECO:0000313|EMBL:PQJ28647.1,
RC ECO:0000313|Proteomes:UP000239907};
RA Song J., Yoshizawa S., Kogure K.;
RT "Study of bacterial adaptation to deep sea.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PQJ28647.1}.
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DR EMBL; MQWA01000001; PQJ28647.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S7U294; -.
DR OrthoDB; 9763310at2; -.
DR Proteomes; UP000239907; Unassembled WGS sequence.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR006293; DNA_helicase_ATP-dep_RecQ_bac.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR029491; Helicase_HTH.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR01389; recQ; 1.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF14493; HTH_40; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:PQJ28647.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000239907}.
FT DOMAIN 32..203
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 224..372
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 530..610
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
SQ SEQUENCE 730 AA; 80588 MW; 28797D32D1D534A8 CRC64;
MNTGNLESAS TLEQLKKLFG FDTFRDHQQE LVEGILSGRD AFGVMPTGGG KSLCYQLPAS
ILPGTAVIVS PLIALMKDQV DSARSNGIKA AFLNSTLAPA EVQAIEKDYI DGNLDLLYLA
PERLSLSNTV SLLRKNQQGA PSFIAIDEAH CISEWGHDFR PDYLFTSRLK ELFPQSPLTA
FTATATEQVA EDIEKRLQLV NPVKIRASFD RKNLFYEVLA KREAPTQIVE FIRERPQQSG
IIYRTSRKSV EETANMLVAN GINAAPYHAG LAAEKRSTTQ DAFIRDDITV MVATVAFGMG
VDKADVRFVI HGDLPKNIES YYQETGRAGR DGEPSHCLLL YSAGDLGKLR FFIEAMPDEA
EQGRARQLLA SMDAFASVPS CRKISLLNYF DETCEVENCG SCDYCAGSFE TVDATRDAQI
VLSAIMRTGS RFGGIHICDI VCGANTAKIR QFEHNKLKTY GVGKDKPKTH WRSVIDALVA
GKKLALSPDK FPVPQINDAA TEILFGRDSF QIAIDKRVVP EKAQHRAEEI DCDHDFFHHL
RALRKELADL EGVPPYVVFS DKALRAMAAY HPSNDTELLN IPGVGQNKLE KYGQRFLSSV
HEYLCNHPDL TPSSKPLKKA AAPRVKQGLT ETFRTTLEML GKGMTPSSIA SERGLGLSTI
ETHVAKLITE GESLDWQLWI DEATNQLCRQ LFAEHGHSAL KPIIEASNGK ITYGQARIIA
AIMQSEKISS
//
