ID A0A2S7W975_9FLAO Unreviewed; 753 AA.
AC A0A2S7W975;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=ATP-dependent DNA helicase RecG {ECO:0000256|ARBA:ARBA00017846, ECO:0000256|RuleBase:RU363016};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551, ECO:0000256|RuleBase:RU363016};
GN Name=recG {ECO:0000256|RuleBase:RU363016};
GN ORFNames=BTO13_02320 {ECO:0000313|EMBL:PQJ74180.1};
OS Polaribacter gangjinensis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae.
OX NCBI_TaxID=574710 {ECO:0000313|EMBL:PQJ74180.1, ECO:0000313|Proteomes:UP000237608};
RN [1] {ECO:0000313|EMBL:PQJ74180.1, ECO:0000313|Proteomes:UP000237608}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KCTC 22729 {ECO:0000313|EMBL:PQJ74180.1,
RC ECO:0000313|Proteomes:UP000237608};
RA Kumagai Y., Yoshizawa S., Kogure K., Iwasaki W.;
RT "Trade-off between light-utilization and light-protection in marine
RT flavobacteria.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Critical role in recombination and DNA repair. Helps process
CC Holliday junction intermediates to mature products by catalyzing branch
CC migration. Has a DNA unwinding activity characteristic of a DNA
CC helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-
CC DNA). {ECO:0000256|RuleBase:RU363016}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363016};
CC -!- SIMILARITY: Belongs to the helicase family. RecG subfamily.
CC {ECO:0000256|ARBA:ARBA00007504, ECO:0000256|RuleBase:RU363016}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PQJ74180.1}.
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DR EMBL; MSCL01000001; PQJ74180.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S7W975; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000237608; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR CDD; cd17992; DEXHc_RecG; 1.
DR CDD; cd04488; RecG_wedge_OBF; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR004609; ATP-dep_DNA_helicase_RecG.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR045562; RecG_dom3_C.
DR InterPro; IPR033454; RecG_wedge.
DR NCBIfam; TIGR00643; recG; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF19833; RecG_dom3_C; 1.
DR Pfam; PF17191; RecG_wedge; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363016};
KW DNA damage {ECO:0000256|RuleBase:RU363016};
KW DNA recombination {ECO:0000256|RuleBase:RU363016};
KW DNA repair {ECO:0000256|RuleBase:RU363016};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU363016};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU363016};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363016};
KW Reference proteome {ECO:0000313|Proteomes:UP000237608}.
FT DOMAIN 283..499
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 518..685
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 439..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 753 AA; 84807 MW; 2ACB47E05D2E7762 CRC64;
MHNLNNPITY INGISVQRAT LLYTELGIKT CRDLLHFFPF RYIDKTQFYQ INQLQPSNAE
VQIVGKITHI KSVAQQKGSR LVATFQDATG TMELVWFKGQ KWIANALKIN EPYVIYGKLN
HFNGSFSMPH PEMQLVTEYQ KKLQSAMQPV YASTEKLASA GISNKLIRTY IESLFKQFYD
GIEETLSHEI LKEQQLISKK EALLNVHFPK SQEALAKGQY RLKFEELFFI QLQLVRKNLL
HKTRIKGIVF KSVGDNFNNF YKYHLPFQLT GAQKRVLKEI RKDVASGIHM NRLLQGDVGS
GKTIVALLSM LLAIDNGFQA ALMAPTEILA TQHFNAIATM LKDMPITVDL LTGSTKTKKR
RTIHEALENG SLHILIGTHA LLEEKVQFYN LGLAIVDEQH RFGVAQRAKL WMKSPSPTLP
KGKGVSTENN NIINSTTKLK SLPLGSPETS GGGEAQLENT LPLGGKGWAP PPHILVMTAT
PIPRTLAMSL YGDLDISVID ELPPGRKEIK TVHRFDSQRL SVLKFMRDEI AKGRQIYVVY
PLIEESEVLD YKDLMDGFES ISREFPMPKY QISIVHGKMT AEKKEFEMQR FVKGETHIMV
ATTVIEVGVN VPNASVMIVE SAERFGLSQL HQLRGRVGRG AEQSYCILMT SAKLSDEAKT
RVKTMVETTD GFKIAEVDLK LRGPGNLMGT QQSGVLNLKI ADLIKDGEIL HLARKTAIKL
LEQDPNMQQE SNERIKKAFN EMTKTAKVWS RIS
//
