ID A0A2S7WZ33_9FLAO Unreviewed; 550 AA.
AC A0A2S7WZ33;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=BTO16_09435 {ECO:0000313|EMBL:PQJ82786.1};
OS Polaribacter glomeratus.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae.
OX NCBI_TaxID=102 {ECO:0000313|EMBL:PQJ82786.1, ECO:0000313|Proteomes:UP000239068};
RN [1] {ECO:0000313|EMBL:PQJ82786.1, ECO:0000313|Proteomes:UP000239068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43844 {ECO:0000313|EMBL:PQJ82786.1,
RC ECO:0000313|Proteomes:UP000239068};
RA Kumagai Y., Yoshizawa S., Kogure K., Iwasaki W.;
RT "Trade-off between light-utilization and light-protection in marine
RT flavobacteria.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PQJ82786.1}.
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DR EMBL; MSCM01000001; PQJ82786.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S7WZ33; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000239068; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004546; Restrct_endonuc_T1M.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR NCBIfam; TIGR00497; hsdM; 1.
DR PANTHER; PTHR42933:SF1; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000239068};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 11..169
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 179..509
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT COILED 481..537
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 550 AA; 62373 MW; 1BF6FB6EFAEB68CE CRC64;
MTAKQQQEQL GKALWDIAND LRGAMNADNF RDYMLSFLFL RYLSDNYEGS VKKELGSDYP
NLEEDDKRTP LSVWYKDNPN DIVPFEQQMR RKVHYVIEPN YLWGSIAELA RKQDEEVLKE
LQKGFKYIEN ESFENSFKGL FSEINLDSEK LGKTYTERNK ALCKIIQSIS EGIADFSTDS
DTLGDAYEYL IGQFAAGSGK KAGEFYTPQQ LSTILSEIVT LDSQNPKAGK KKKLNKLLDI
TCGSGSLLLN VKDKIEKAGG TISRIYGQEK NITTYNLARM NMLLHGVKSS EFEIFHGDTL
KNEWDVFNEM NPAKKVTFDA VVANPPFSLR WDASEAMGEN FRYKNYGLAP KSAADFAFLL
HGFHFLSDEG TMAIILPHGV LFRGGAEARI RTKLLKDGHI DTVIGMPSNL FFSTGIPVCI
LVLKKCKKDN DVLFINASEH YKKEKNQNTL RDGKVDGVLD PKAPNDIKKI IDTYQNRPEN
IERYARRVSM AEIEKNDYNL NISRYVSTAI AEKIINLKEV NTKIVEVEIK SAKALEEHNG
YLKELGLDTI
//
