ID   A0A2S8A7W6_9FLAO        Unreviewed;       448 AA.
AC   A0A2S8A7W6;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Multidrug export protein MepA {ECO:0000256|ARBA:ARBA00022106};
GN   ORFNames=C4S77_12325 {ECO:0000313|EMBL:PQL90653.1};
OS   Apibacter adventoris.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC   Apibacter.
OX   NCBI_TaxID=1679466 {ECO:0000313|EMBL:PQL90653.1, ECO:0000313|Proteomes:UP000238042};
RN   [1] {ECO:0000313|EMBL:PQL90653.1, ECO:0000313|Proteomes:UP000238042}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=wkB301 {ECO:0000313|Proteomes:UP000238042};
RA   Kwong W.K., Steele M.I., Moran N.A.;
RT   "Genome sequences of Apibacter spp., gut symbionts of Asian honey bees.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. MepA subfamily. {ECO:0000256|ARBA:ARBA00008417}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PQL90653.1}.
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DR   EMBL; PSZM01000046; PQL90653.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S8A7W6; -.
DR   OrthoDB; 9811110at2; -.
DR   Proteomes; UP000238042; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd13143; MATE_MepA_like; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR045070; MATE_MepA-like.
DR   InterPro; IPR048279; MdtK-like.
DR   NCBIfam; TIGR00797; matE; 1.
DR   PANTHER; PTHR43823:SF3; MULTIDRUG EXPORT PROTEIN MEPA; 1.
DR   PANTHER; PTHR43823; SPORULATION PROTEIN YKVU; 1.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000238042};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        20..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        96..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        139..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        172..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        199..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        237..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        322..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        361..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        391..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        419..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   448 AA;  49048 MW;  93B247C8E0DCAC61 CRC64;
     MENKGLPLEL GTKDIGKLLL QYSLPAIIAM TASSLYNITD SIFIGHGIGP LAIAGLAITF
     PLMNLASAFG SLVGVGASTL LSVKLGQKDY STANNILGNV VTMNLIMGIA YSIVMLLFLN
     PILYFFGASN ITLPYAHDFM VIILLGNVVT HMYLGLNALL RSAGSPEKAM FATIFTVIIN
     LILNPLFIFV FHWGIRGSAL ATVISQITVL SWQIYLFNNK NNFLHFQKGT FKLKRRIVID
     SLSIGMSPFL MNTASCIIVI LINKGLLKYG GDLAVGAYGI INRIAFLFVM ITIGLNQGMQ
     PIAGYNYGAA HYSRVRKVLK KAITYATIIM SIGFIIVQLT PHTVASIFTS DQKLIDLSTT
     GLRIVFIFYP IVGFQMVTST FFQSIGMPNK AIFLSLTRQV LFLIPCLLIL PHFFGITGIW
     ASMPIADFVA CTVAAIMLYF QFAKIKNK
//