ID   A0A2S8A948_9FLAO        Unreviewed;      1049 AA.
AC   A0A2S8A948;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=CusA/CzcA family heavy metal efflux RND transporter {ECO:0000313|EMBL:PQL91040.1};
GN   ORFNames=C4S77_09300 {ECO:0000313|EMBL:PQL91040.1};
OS   Apibacter adventoris.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC   Apibacter.
OX   NCBI_TaxID=1679466 {ECO:0000313|EMBL:PQL91040.1, ECO:0000313|Proteomes:UP000238042};
RN   [1] {ECO:0000313|EMBL:PQL91040.1, ECO:0000313|Proteomes:UP000238042}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=wkB301 {ECO:0000313|Proteomes:UP000238042};
RA   Kwong W.K., Steele M.I., Moran N.A.;
RT   "Genome sequences of Apibacter spp., gut symbionts of Asian honey bees.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PQL91040.1}.
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DR   EMBL; PSZM01000043; PQL91040.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S8A948; -.
DR   OrthoDB; 9758757at2; -.
DR   Proteomes; UP000238042; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004763; CusA-like.
DR   NCBIfam; TIGR00914; 2A0601; 1.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF12; CATION EFFLUX SYSTEM PROTEIN; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000238042};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        17..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        344..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        367..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        393..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        450..468
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        480..504
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        540..558
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        873..892
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        899..917
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        923..950
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        971..990
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1002..1029
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1049 AA;  117073 MW;  960C0565F496CE0A CRC64;
     MNKFIKGILT FSLKNKFFTF FWVLILIIAG IICFKNTPID AFPDVTNTQI VIITKWNGRS
     AEEVERFVTT PIEVAMNSVQ KKASVRSVSM FGLSVIKIIF NDNVDDFFAR QQVNNQLSTI
     DFPEGVSPEV QPPYGPTGEI YRYVLSSKTE NTRDLLTLQN WVLDRQLRSV PGVADINVFG
     GQDKIYELHV DPSKLIKYDL SPLEVYEAVN GSNLNVGGDI IEKNDQAFVV RGVGLLDNKE
     DIKNIIIKSE SGNPILVKNV ASVVETSMPR VGQAGYQNKK ENQNDVVEGI VVMRKGENTS
     EVLKALKQKI SEIKKTTIPA DVQMKTVYDR DNLMDYCMHT VSHNLVEGIV LVTVIVFLFM
     GDWRTTIIVS IVIPLALLFA FICLRIKGMS ANLISLGAID FGIIIDGAVV MVEGIFVTLD
     HLAKKRGIET FNKLSKLGLI RSTGTELGKA VFFSKLIIIT ALMPIFAFQK VEGKMFSPLA
     WTLGFALLGA LIFTLTLVPV LSSILLNKNV KEKHTFLVRI INKYIFSAFR WCYHYQKKSI
     TIAFIILILT LFSTRWLGTE FLPKLNEGAL WVTAEMPMST NLSESMKITE ALRNKLLEFP
     EVNEVISNTG RSNDGTDPNG FNFTQFQVTL KPKSEWKRKI SLDELIDDMD HSLKEYQGIV
     YNYSQPVSDN VAEAVAGFKA ENAVKIFGPN QYVLDSLAKA CYNQIKDVPG IKDAGVLKNI
     GQPEVSIKLD EQKMALYGVT KKDAQAVIEM AIGGKTATEK FEGEKKFDVR IRYDKNYRKN
     EQDFKRLMVP TISGSLIPLN EISNISAHTG PAFVYRDDLK RFIGVKFSVR DRDLGSTIAE
     AQQKINKNIK LPKGYSFGWT GEFENQVRAT HRLGQVVPIS LLIIYFLLFI MFGNAKEAGI
     VLLNVPFALI GGIWALFITG TNFGISAGVG MIALFGICVQ NGVILVSVFN KLLKEGHHLI
     DAIKEGVKSR IRPVVMTALM ASIGLMPAAT SHGIGSENQR PLAIVIIGGL VTATFFTLLV
     FPVFCHWFYS GRLRKLQERK ERKNTLRGS
//