ID A0A2S8ESF0_9RHOB Unreviewed; 1832 AA.
AC A0A2S8ESF0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=PAN domain-containing protein {ECO:0000313|EMBL:PQO22802.1};
GN ORFNames=C2I36_11125 {ECO:0000313|EMBL:PQO22802.1};
OS Rhodobacteraceae bacterium WD3A24.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae.
OX NCBI_TaxID=2086263 {ECO:0000313|EMBL:PQO22802.1, ECO:0000313|Proteomes:UP000237945};
RN [1] {ECO:0000313|EMBL:PQO22802.1, ECO:0000313|Proteomes:UP000237945}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WD3A24 {ECO:0000313|EMBL:PQO22802.1,
RC ECO:0000313|Proteomes:UP000237945};
RA Wang S.;
RT "The draft genome sequence of Pararoseibaca halophilus WD3A24.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PQO22802.1}.
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DR EMBL; PUHN01000036; PQO22802.1; -; Genomic_DNA.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000237945; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR CDD; cd01100; APPLE_Factor_XI_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR InterPro; IPR026284; A2-macglob_dom_prot_bac.
DR InterPro; IPR049120; A2M_bMG2.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR000177; Apple.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041462; Bact_A2M_MG6.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF21142; A2M_bMG2; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF17962; bMG6; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF07678; TED_complement; 1.
DR PIRSF; PIRSF038980; A2M_bac; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000237945};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1832
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015782953"
FT DOMAIN 964..1108
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1170..1259
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1832 AA; 194680 MW; 96BB841F5B024D41 CRC64;
MVAFVNRCLA LVLAVLASGA PALAQEDSPV PARRAAIIDD MDYPGADLRQ LFDTTFPACL
QACRDDDACA GFTYNTRNGS CFPKAGLGAP QPYQGAVSGR MIPTDPAVLS RAEALRERMD
FLPASDFDAA RALAEELPTL YTANEWSAGD HAAAAEDALR RNAYAAAARS YGAALTVGDA
ADHWLAYAEA TRRITGSDRA DERRMRARAR AAALNAALRA GDATLRAEAL VAFAVLLEPA
GRGRDMIPVL RLAQEIAPGR RGAALLERAV REYGFRVVDH RVESDSARPR VCAVFSEPLV
QAGLDYAPYV RVSTGGIAVE AEERALCVDG LAHGTRYQIT LREGLPAASG EVLARSVPLD
VYVRDRAASV RFPGRAYVLP AAGDLALPVE TVNTDALELE LMRVSDRNLV RAIRDDQLAR
PLSRWEEMQF SEEMATEVWE GEAEVGMDLN AEVTTRLPLA EVMGDLPTGV YVLHAAVPGT
DPFDVPAATQ WFVVSDLGLS TMQGADGLHV VVRSLETADA RADVEVALVS RVNEVLATAT
TDSRGYAHFP PGLTRGTGSD APALVTAEAG AGETVEDIAF LSLTDPEFDL SDRGVEGRAP
APPVDVFLTT ERGAYRAGET VHVTALARDG DARAIEGLPL TARFLRPDGV EYARMQAGAT
AAGGHVFEQE LGGGVPRGAW RVQIHADPDE PPLAEQSFLV EDFLPERIDF EMALPDAPIR
PGDRPRLSID ARYLFGAPAA DLPIAGRVTL RPAEEGLADW PGFGFGRHDA DVTPARTVFP
SGVTTDADGA ARIPLTLPEI ETRDRPLEIE VVAEISEGSG RPVERDLTRT LAPDAPMMGL
RPAFEGGVVP EGGEAGFDVI ATGPDGAAVP ARAEWTLNRV RTRYQWYSVR GDWFWEPVTT
RTRVAGGEIA LDGTGPARIA APVEWGRYEL VVARTDGDSH AAASTTFDAG WYAPAGVLDS
PDMLELSLDS ESYRPGDTAR LRVVPRAAGT ALVSVLSNRL IDMQVVEVPE GESVIELPVT
EEWGTGAYVT ASVLRPMDPD AGRNPARALG LAHAAIDPGP RRLEAEFEAP AEADPRGPLD
VALRVDGMAE GETAWATIAA VDEGILNLTG FEPPDPEGHY FGQRRLGMGL RDVYGRLIDG
MSGAMGVVRS GGDAMATMRR EAPPPTEELV AYFSGPVEVG PDGLARASFD LPAFNGTVRL
MGVAWSRGGV GQASADVLVR DPVVVNASLP RFLAPGDDSR LLLELTHTSG PAGRMAIDVD
APPALRLGDV PGQVELSAEG RARLSIPLTA QKPGTHRIAV TVTTPDGRRL DRRLTLPVEA
HDPEIARTST LTLDPGETLR FGADIFEGLR PGTGSATLAA GPLARLDIAG LMRRLDAYPY
GCAEQVTSTA TALLVMPELA ADMGIAGPDE ARTRIEAAID RVLTYQAPNG AFGLWRAGTG
DLWLDAYVTD FLARARERGF EVPDTAFRAA MDNLRNRLNY APDFEEDGGP WAYALMVLAR
EGAAAVGDLR YYADVKASAF DTPLAAAQLG TALAAYGDTG RADAMFSQAA RLAREGGDEH
GGGWREDYGT PLRDTAGLLA LAAESGSGAV DRSALAQSLA EGLTSRRAAR GMSPQEAAWS
LRAAGALTDA AADSGLAVNG APVSGPVVRM IEDTVRGGRP VTVANTGTGP AEVMLTAFGV
PVTAPPAEGR GYRIERSHYT LEGEPITLES VPVGTRVVTV LRVTPLGTGG GRLMVDDPLP
AGFEIDNPNL LRAGDIAALD WLDLDDVAEH TEARDARFLA AVDWREDESF RLGYIARAVT
PGSYRHPAAS VEDMYRPMRR AITDTGRATV VE
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