ID A0A2S9H3P1_9BURK Unreviewed; 318 AA.
AC A0A2S9H3P1;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE SubName: Full=Phosphoglycerate dehydrogenase and related dehydrogenase {ECO:0000313|EMBL:PRC94486.1};
GN ORFNames=S2091_0489 {ECO:0000313|EMBL:PRC94486.1};
OS Solimicrobium silvestre.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Solimicrobium.
OX NCBI_TaxID=2099400 {ECO:0000313|EMBL:PRC94486.1, ECO:0000313|Proteomes:UP000237839};
RN [1] {ECO:0000313|EMBL:PRC94486.1, ECO:0000313|Proteomes:UP000237839}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S20-91 {ECO:0000313|EMBL:PRC94486.1,
RC ECO:0000313|Proteomes:UP000237839};
RA Margesin R., Albuquerque L., Zhang D.-C., Froufe H.J.C., Severino R.,
RA Roxo I., Egas C., Da Costa M.S.;
RT "Solimicrobium silvestre gen. nov., sp. nov., isolated from alpine forest
RT soil.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRC94486.1}.
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DR EMBL; PUGF01000002; PRC94486.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S9H3P1; -.
DR Proteomes; UP000237839; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd12169; PGDH_like_1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42789; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR PANTHER; PTHR42789:SF1; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000237839}.
FT DOMAIN 21..315
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 112..291
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 318 AA; 34754 MW; 382FF81461CD9367 CRC64;
MMKIAILDDV QDVVKNLSCF SLLQDHDVKI FTNSARGIGQ VAIRLAPFDA IVLIRERTAM
PRALLQKLPN LKLISQTGKV AGHIDLDAAA ELGITIAEGI GDPTAPAELA WALIMAAMRK
IPQYASNLRE GTWQTVSSNP VHNTLGSRLK GKTLAIWGYG KIGQLVAGYG RAFGMQVLVW
GREASREKAL QDGYVVAASK EEFFTRADVL SLHLRLNEAT RGIVLDSDLK RLKPSALFVN
ISRAELVEEG ALLTAVTQGQ PAALDVFDAE PLAHDSPLLR LPNVLATPHL GYVEQQSYEI
YFEAAFQNIV DYAKRELA
//
