ID A0A2S9PV74_9ACTN Unreviewed; 560 AA.
AC A0A2S9PV74;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Bifunctional 3'-5' exonuclease/DNA polymerase {ECO:0000313|EMBL:PRH78324.1};
GN ORFNames=C6N75_15510 {ECO:0000313|EMBL:PRH78324.1};
OS Streptomyces solincola.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2100817 {ECO:0000313|EMBL:PRH78324.1, ECO:0000313|Proteomes:UP000239322};
RN [1] {ECO:0000313|EMBL:PRH78324.1, ECO:0000313|Proteomes:UP000239322}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ST5x {ECO:0000313|EMBL:PRH78324.1,
RC ECO:0000313|Proteomes:UP000239322};
RA Tan G.Y.A., Lee Z.Y.;
RT "Novel Streptomyces sp. from soil.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRH78324.1}.
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DR EMBL; PVLV01000217; PRH78324.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S9PV74; -.
DR OrthoDB; 4414061at2; -.
DR Proteomes; UP000239322; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd06444; DNA_pol_A; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:PRH78324.1};
KW Hydrolase {ECO:0000313|EMBL:PRH78324.1};
KW Nuclease {ECO:0000313|EMBL:PRH78324.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000239322}.
FT DOMAIN 311..519
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 8..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 560 AA; 60261 MW; 61313E7862727AC8 CRC64;
MSERWLVEAT EDGGARLAPL GEDGRPAGPV RAEPDLAAAV GARPDAARWV WRSTAEVYPR
LLAAGVRVER CYDIEDAEQL LLGHEGRSGE PRSAAAAFAR LRRRPVPADP PQRAAVPGAQ
SSLFEPGPAA LPFDALLEVY AEQVRRHDAA GHPGRMRLLT AAESAGMLVA AEMNRAGLPW
RADVHRRLLD DMLGERYGGG GEPRRLAELA EEVSAAFGRR VRPDLPADVL RAFAQAGITV
KSTRRWELER VDHPAVAPLV AYKKLYRIWT AHGWGWLQDW VREGRFRPGY LPGGTVSGRW
TTNGGGALQI PRIIRRAVVA DPGWRLVVAD ADQMEPRVLA AISRDQGLME VAGDPGDLYA
RLSDRAFSGD RDQAKIALLG AVYGQTSGDG LKNLAALRRR FPLAVAYVDD AARAGEEGRL
VRTWLGRTSP RAVGAEEAEE AGLPQEPAAA AREGGGVPGY ASSDARARGR FTRNFVVQGS
AADWALLMLA ALRRSLAGMA AELVFFQHDE VIVHCPADEA PEVAAAIGAA GDTAGRIAFG
ETPVRFPFTT ATVECYADAK
//
