ID A0A2S9Q338_9ACTN Unreviewed; 689 AA.
AC A0A2S9Q338;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=Protein-L-isoaspartate O-methyltransferase {ECO:0000256|ARBA:ARBA00013346};
DE EC=2.1.1.77 {ECO:0000256|ARBA:ARBA00011890};
DE AltName: Full=L-isoaspartyl protein carboxyl methyltransferase {ECO:0000256|ARBA:ARBA00031350};
DE AltName: Full=Protein L-isoaspartyl methyltransferase {ECO:0000256|ARBA:ARBA00030757};
DE AltName: Full=Protein-beta-aspartate methyltransferase {ECO:0000256|ARBA:ARBA00031323};
GN Name=fxlM {ECO:0000313|EMBL:PRH81094.1};
GN ORFNames=C6N75_00700 {ECO:0000313|EMBL:PRH81094.1};
OS Streptomyces solincola.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2100817 {ECO:0000313|EMBL:PRH81094.1, ECO:0000313|Proteomes:UP000239322};
RN [1] {ECO:0000313|EMBL:PRH81094.1, ECO:0000313|Proteomes:UP000239322}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ST5x {ECO:0000313|EMBL:PRH81094.1,
RC ECO:0000313|Proteomes:UP000239322};
RA Tan G.Y.A., Lee Z.Y.;
RT "Novel Streptomyces sp. from soil.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. L-
CC isoaspartyl/D-aspartyl protein methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005369}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRH81094.1}.
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DR EMBL; PVLV01000007; PRH81094.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S9Q338; -.
DR OrthoDB; 4035289at2; -.
DR Proteomes; UP000239322; Unassembled WGS sequence.
DR GO; GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR027573; Methyltran_FxLD.
DR InterPro; IPR000682; PCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR023809; Thiopep_bacteriocin_synth_dom.
DR NCBIfam; TIGR04364; methyltran_FxLD; 1.
DR NCBIfam; TIGR03891; thiopep_ocin; 1.
DR PANTHER; PTHR11579; PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11579:SF0; PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE; 1.
DR Pfam; PF14028; Lant_dehydr_C; 1.
DR Pfam; PF01135; PCMT; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:PRH81094.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000239322};
KW Transferase {ECO:0000313|EMBL:PRH81094.1}.
FT DOMAIN 6..252
FT /note="Thiopeptide-type bacteriocin biosynthesis"
FT /evidence="ECO:0000259|Pfam:PF14028"
SQ SEQUENCE 689 AA; 73785 MW; CC6084973E52F2F4 CRC64;
MCSDRWQQHN ITFPDRDTGR CAVTERLAPA LLAAEADGQL SGWWFINKQP WRLRYVADQP
APTVLTLLDE WVADGTAQSH TTAIYEPETE AFGGADAMTA AHALFHEDSR HLLAYPVQDG
HLGRRETTVL LLSSLMRAAN LDWFEQGDVW AKVCALRPGT STPASTRLIS AMRTLMTTEA
RGLCREGGPL DGHADWVAAF ERAGTTLAYL AVQGALTRGL RAVIAHHAIF HANRAGLPGA
DQHTLFHIAR EVVMGSSENT ASAAESGSAA NSVSAVNTDT LTAPEANAEQ LRNALVDQIQ
ADGHARTPAV EAALRTVPRH LFVPEAPLAD AYANDPVHVK YDPEGTSISC ASQPAVVALM
LDQLEAQPGE RILELGAGTG YNAALIGHLV GPSGHVTTID VDDDLVEGAR AHLAAAGVTN
VEALTRDGAL GHAEGAPYDR IIATVGAHGI PHAWLEQLAE GGRLVTPQRL TGSVSRSIIY
VKRDGRWQSA GSEMNTFMPL RRGIADDDRR AVPLSTDGAV RLQAPAGLAI DADALAGVLD
QPRVEEWTGM TVRAGESPEW MELFVSCVMP SGLIRMLFPK SAKGTVLTED PYPSATAAVD
KGAVTYLARR PSAEKTPEGD KLWEFGVIGH GPGSDELAAK VADAVRTWDR EYRGRDAAFE
ILPLGAPADE QPGVFVLDTP LNRVRVTWQ
//
