ID A0A2S9QLA3_9MICO Unreviewed; 341 AA.
AC A0A2S9QLA3;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=B4915_11970 {ECO:0000313|EMBL:PRI10367.1};
OS Leucobacter massiliensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Leucobacter.
OX NCBI_TaxID=1686285 {ECO:0000313|EMBL:PRI10367.1, ECO:0000313|Proteomes:UP000238650};
RN [1] {ECO:0000313|EMBL:PRI10367.1, ECO:0000313|Proteomes:UP000238650}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=122RC15 {ECO:0000313|EMBL:PRI10367.1,
RC ECO:0000313|Proteomes:UP000238650};
RX PubMed=29204283;
RA Leangapichart T., Gautret P., Nguyen T.T., Armstrong N., Rolain J.M.;
RT "Genome sequence of 'Leucobacter massiliensis' sp. nov. isolated from human
RT pharynx after travel to the 2014 Hajj.";
RL New Microbes New Infect 21:42-48(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRI10367.1}.
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DR EMBL; MWZD01000020; PRI10367.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S9QLA3; -.
DR OrthoDB; 9778962at2; -.
DR Proteomes; UP000238650; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 1.10.132.120; -; 1.
DR Gene3D; 3.30.66.10; DNA topoisomerase I domain; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR035447; DNA_topo_I_N_sf.
DR InterPro; IPR049331; Top1B_N_bact.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR Pfam; PF21338; Top1B_N_bact; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF55869; DNA topoisomerase I domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:PRI10367.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000238650};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 31..73
FT /note="DNA topoisomerase IB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21338"
FT DOMAIN 85..293
FT /note="DNA topoisomerase I catalytic core eukaryotic-type"
FT /evidence="ECO:0000259|Pfam:PF01028"
SQ SEQUENCE 341 AA; 38787 MW; 40B384629399E52A CRC64;
MSGASGTAPR RRRRRLPISR ELEGEAFVYR LRGRKITRRA EIARIEALAI PPAWTEVEIA
KSPTAKVLAR GVDAAGRTQA IYHPSFRKRQ DRIKFARLER FGRALPRIRA RVDRDLRRRL
LGPDRVTACV VRLIDLQFFR VGNVQYAKRH RSFGITTLRR EHVTVSSGGV TFDFTGKSGK
RHRRRVSDER VARLLARVQE ELPGPELFRF IDEDGVAHPL RSGHVNGYVR RHMGEEFTAK
DFRTWGGTVV AANALLDLEP GQLRTKTARS RAVRGALEAA AERLGNTVAV TKASYVDPRV
LAAAERPRVL RRVRESRERM RPRRHFDVAE QATLALLAEM S
//
