ID A0A2S9QSR3_9MICO Unreviewed; 173 AA.
AC A0A2S9QSR3;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase {ECO:0000256|ARBA:ARBA00013253};
DE EC=2.7.6.3 {ECO:0000256|ARBA:ARBA00013253};
GN ORFNames=B4915_00655 {ECO:0000313|EMBL:PRI12609.1};
OS Leucobacter massiliensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Leucobacter.
OX NCBI_TaxID=1686285 {ECO:0000313|EMBL:PRI12609.1, ECO:0000313|Proteomes:UP000238650};
RN [1] {ECO:0000313|EMBL:PRI12609.1, ECO:0000313|Proteomes:UP000238650}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=122RC15 {ECO:0000313|EMBL:PRI12609.1,
RC ECO:0000313|Proteomes:UP000238650};
RX PubMed=29204283;
RA Leangapichart T., Gautret P., Nguyen T.T., Armstrong N., Rolain J.M.;
RT "Genome sequence of 'Leucobacter massiliensis' sp. nov. isolated from human
RT pharynx after travel to the 2014 Hajj.";
RL New Microbes New Infect 21:42-48(2017).
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-
CC 4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-
CC dihydroneopterin triphosphate: step 4/4.
CC {ECO:0000256|ARBA:ARBA00005051}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRI12609.1}.
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DR EMBL; MWZD01000008; PRI12609.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S9QSR3; -.
DR OrthoDB; 9808041at2; -.
DR UniPathway; UPA00077; UER00155.
DR Proteomes; UP000238650; Unassembled WGS sequence.
DR GO; GO:0003848; F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046656; P:folic acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00483; HPPK; 1.
DR Gene3D; 3.30.70.560; 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; 1.
DR InterPro; IPR000550; Hppk.
DR InterPro; IPR035907; Hppk_sf.
DR NCBIfam; TIGR01498; folK; 1.
DR PANTHER; PTHR43071; 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR43071:SF1; 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE; 1.
DR Pfam; PF01288; HPPK; 1.
DR SUPFAM; SSF55083; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Folate biosynthesis {ECO:0000256|ARBA:ARBA00022909};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:PRI12609.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000238650};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 10..141
FT /note="7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase"
FT /evidence="ECO:0000259|Pfam:PF01288"
SQ SEQUENCE 173 AA; 18780 MW; 64CB76852B7B20E0 CRC64;
MIAQIVPVLF AFGANLGDRG ETIRAAQRAL AAAPGIRDFS ASPLRETIAL TERGPDPEAP
RYLNGVASAQ TALTPHELLD LTQRLEADHG RVRDARWGDR TLDIDLILYG GRVVRDERLT
IPHPRAHERD FVLAPWLALD PDAVLMGHGR VDALLARIGD TTAPFAEPGD AQA
//
