ID A0A2T0BAK7_9CLOT Unreviewed; 747 AA.
AC A0A2T0BAK7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=recQ {ECO:0000313|EMBL:PRR80936.1};
GN ORFNames=CLLU_32660 {ECO:0000313|EMBL:PRR80936.1};
OS Clostridium luticellarii.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1691940 {ECO:0000313|EMBL:PRR80936.1, ECO:0000313|Proteomes:UP000237798};
RN [1] {ECO:0000313|EMBL:PRR80936.1, ECO:0000313|Proteomes:UP000237798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 29923 {ECO:0000313|EMBL:PRR80936.1,
RC ECO:0000313|Proteomes:UP000237798};
RA Poehlein A., Daniel R.;
RT "Genome sequence of Clostridium luticellarii DSM 29923.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRR80936.1}.
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DR EMBL; PVXP01000080; PRR80936.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T0BAK7; -.
DR Proteomes; UP000237798; Unassembled WGS sequence.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.10.1390; ATP-dependent DNA helicase RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR006293; DNA_helicase_ATP-dep_RecQ_bac.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR029491; Helicase_HTH.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR01389; recQ; 1.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF14493; HTH_40; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:PRR80936.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:PRR80936.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000237798}.
FT DOMAIN 55..224
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 245..392
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 543..623
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
SQ SEQUENCE 747 AA; 85417 MW; 1F3BA7D54DDAD957 CRC64;
MCFVHVFWPD TALYGIICLE YITSTGVNTL IDSALEVLHK YYGYDDFRGD QNKVIESILD
GKDTMAIMPT GGGKSICYQI PALLFKGITI VISPLISLMK DQVDSMKDLG IGAAYINSSI
TQSEILNICS ALKKGDVKIL YVAPERLESG EFCHFIKGMD ISQVAVDEAH CVSQWGHDFR
VSYTYIDQFI ENLSIRPVVT AFTATATEEV RKDIVSQIKL KNPAVFISGF DRANLKISCL
KGGNRFRHML DYIRTNGQQS GIVYAATRRE VDSIYEKLRA NDISAGRYHG GMSNEDRKKN
QEDFVYDRIS VIVATNAFGM GIDKSNVRFV IHYNIPKNIE SYYQEIGRAG RDGEKSECIL
MFAPQDVITQ KYLIETSIQS PERRLNEYKK LQCMVDFVHY NGCLRKYILN YFGEQVDYEE
CGNCSNCITK GEYVDKTVDC QKVLSCIYRM KREFGVNMIV DVLRGSLQKK VLQYGFDKIS
TYGIMKNYSK NELSSFINTL IAQGYISLRE GEYPMVVLNS HSVKILKGEE KVILKEPARA
EKIIENSDLF EILRNLRREI AGRESIPPYL VFADATLREI SSRYPVTSQQ MLDISGVGEL
KLEKYGDVFL NVIREYVEKN KIHPDWYFRK NFSEESGRKN NKLRTFEITV SMLKNNMSIE
EVSKKRELTV STVLSHITKY LEQGEKSNLK IKFDDLFTKD EENVILKVIK KLGISRLKPI
KESLPDSISY DMIKAVILKD FILENYN
//
