ID A0A2T0FHV6_9ASCO Unreviewed; 669 AA.
AC A0A2T0FHV6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Calcium-binding mitochondrial carrier protein Aralar1 {ECO:0000313|EMBL:PRT54581.1};
GN ORFNames=B9G98_02201 {ECO:0000313|EMBL:PRT54581.1};
OS Wickerhamiella sorbophila.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Trichomonascaceae; Wickerhamiella.
OX NCBI_TaxID=45607 {ECO:0000313|EMBL:PRT54581.1, ECO:0000313|Proteomes:UP000238350};
RN [1] {ECO:0000313|EMBL:PRT54581.1, ECO:0000313|Proteomes:UP000238350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS02 {ECO:0000313|EMBL:PRT54581.1,
RC ECO:0000313|Proteomes:UP000238350};
RA Ahn J.O.;
RT "Genome sequencing of [Candida] sorbophila.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer (via N-terminus). {ECO:0000256|ARBA:ARBA00038674}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRT54581.1}.
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DR EMBL; NDIQ01000021; PRT54581.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T0FHV6; -.
DR STRING; 45607.A0A2T0FHV6; -.
DR OrthoDB; 1220009at2759; -.
DR Proteomes; UP000238350; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0043490; P:malate-aspartate shuttle; IEA:UniProt.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45678:SF9; CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1; 1.
DR PANTHER; PTHR45678; MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED; 1.
DR Pfam; PF00036; EF-hand_1; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000238350};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 84..119
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 156..191
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REPEAT 331..422
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 430..517
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 527..615
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 669 AA; 75354 MW; C0880E251A7E05DE CRC64;
MNLSEPKRHD ASKQRFLKHA THRDEQGNLY LSEQDFVEAV APPNENYEKV HRNSYAVLFG
VADHSKQGRV SLNDWLAFDN LLEQPDAEFQ IAFRVFDTEG AGYVNFKEFV NIYNANRSSN
SLPFDWNSKW AALYLGESGQ RHNMSYQQFS QMVSGLVGER IRQAFQHFDK KKTGFITPDE
FEEIMKRTAQ HKLSNSLLEN LHTVTQRPNS ISSKVSYATV RAFVNLVNHT EYVEKIARES
SRDNHFTRKD FMENAARSAR FLNFTPLEID LLFHFANDGD SNDSASLEKF EQMFNPQWQD
VYSRYHAAQQ HKVAAAKNAA SDPRSFLSEV FESVYNFTLG SVAGAFGATV VYPIDLVKTR
MQNQRKAKPG QALLYKNSWD CFKKTVHNEG FRGLYSGLGP QLIGVAPEKA IKLTVNDLVR
GIMTKPDGSL DLWAEIMAGG SAGACQVVFT NPLEIVKIRL QVQGEMARHE GVPKRSAVHI
VRQLGLVGLY KGATACLLRD VPFSAIYFPT YAHLKKDYFN EGPGHPLKTW QLLVAGAVAG
IPAAYLTTPF DVIKTRLQVE SRKGMTQYNG LRHAASIIWH EEGFTAFFKG GPARILRSSP
QFGCTLAAYE VLKRLLPFPG SGKNSEAGHS VRTADFAPEP PVKYLRSRNS LKVLLDIDEN
FGKPWAKKF
//
