ID A0A2T0FJV4_9ASCO Unreviewed; 475 AA.
AC A0A2T0FJV4;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=B9G98_02878 {ECO:0000313|EMBL:PRT55258.1};
OS Wickerhamiella sorbophila.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Trichomonascaceae; Wickerhamiella.
OX NCBI_TaxID=45607 {ECO:0000313|EMBL:PRT55258.1, ECO:0000313|Proteomes:UP000238350};
RN [1] {ECO:0000313|EMBL:PRT55258.1, ECO:0000313|Proteomes:UP000238350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS02 {ECO:0000313|EMBL:PRT55258.1,
RC ECO:0000313|Proteomes:UP000238350};
RA Ahn J.O.;
RT "Genome sequencing of [Candida] sorbophila.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRT55258.1}.
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DR EMBL; NDIQ01000021; PRT55258.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T0FJV4; -.
DR STRING; 45607.A0A2T0FJV4; -.
DR OrthoDB; 3639304at2759; -.
DR Proteomes; UP000238350; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:PRT55258.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000238350}.
FT DOMAIN 42..382
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 475 AA; 52457 MW; 6D3BE95175BE4C4B CRC64;
MPLRAKIDPT RLNINARMNH TSSSYEEGSP DEVLVRSNGA VREFILNRPK KLNAINHNMC
TLMAPRLLEY AKSDSANIIV VKGAGGKAFS AGGDVTALAL MFREQGAEVG EKNCSRYFQT
EFALDHLIAT YAKPYVALID GITMGGGVGL SAHAPFVVAT EKTLWAMPET TIGYYPDVGG
LFRLSRMDGQ LGLYLGMTSD RLKGYDVYRA GVATHFVPSE RVPEIEKRLS ELRPSDGDAT
SDEYFSLVNR AIEEFAADAP ANHKPTLSDA DRDVIDSCFK FDTVEEIIAA LEAEGSAFAL
KTKATLLDRC PHSLKVTLAG FRKAKSLDIK SVFALEQHIA DGVCGRNDFA EGVIALLVDK
RKPVWEPASL EQISASDIAK IFAPRKPDWT PMKFHTDRTY MQYPHKFGLP TEEEIMLFVT
GETSSSETKA TRDDVVKHFE KTHGNKVGLV SHIEHVLARK TKADPQHPTL LDWTY
//
