ID A0A2T0FLC3_9ASCO Unreviewed; 542 AA.
AC A0A2T0FLC3;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=NADH:ubiquinone reductase (non-electrogenic) {ECO:0000256|ARBA:ARBA00012637};
DE EC=1.6.5.9 {ECO:0000256|ARBA:ARBA00012637};
GN ORFNames=B9G98_03392 {ECO:0000313|EMBL:PRT55772.1};
OS Wickerhamiella sorbophila.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Trichomonascaceae; Wickerhamiella.
OX NCBI_TaxID=45607 {ECO:0000313|EMBL:PRT55772.1, ECO:0000313|Proteomes:UP000238350};
RN [1] {ECO:0000313|EMBL:PRT55772.1, ECO:0000313|Proteomes:UP000238350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS02 {ECO:0000313|EMBL:PRT55772.1,
RC ECO:0000313|Proteomes:UP000238350};
RA Ahn J.O.;
RT "Genome sequencing of [Candida] sorbophila.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinone + H(+) + NADH = a quinol + NAD(+);
CC Xref=Rhea:RHEA:46160, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124; EC=1.6.5.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000864};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + H(+) + NADH = a ubiquinol + NAD(+);
CC Xref=Rhea:RHEA:23152, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945;
CC Evidence={ECO:0000256|ARBA:ARBA00000891};
CC -!- SIMILARITY: Belongs to the NADH dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00005272}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRT55772.1}.
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DR EMBL; NDIQ01000022; PRT55772.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T0FLC3; -.
DR STRING; 45607.A0A2T0FLC3; -.
DR OrthoDB; 1434722at2759; -.
DR Proteomes; UP000238350; Unassembled WGS sequence.
DR GO; GO:0003954; F:NADH dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006116; P:NADH oxidation; IEA:InterPro.
DR Gene3D; 3.50.50.100; -; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR045024; NDH-2.
DR PANTHER; PTHR43706:SF3; EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43706; NADH DEHYDROGENASE; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR PRINTS; PR00368; FADPNR.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000238350};
KW Ubiquinone {ECO:0000313|EMBL:PRT55772.1}.
FT DOMAIN 73..413
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
SQ SEQUENCE 542 AA; 60757 MW; 8A6844F4938E44DC CRC64;
MRLRAPVRMM SVSASRMNAG PVLPAGRKPS RFFRNIKWLF GLTIGVGVGF CAYRIQQHRF
PAAQEPVPEG KKRLLVLGSG WGSVSVLKNV DSREYDITVV SPRNYFLFTP LLPSCTTGCI
EHRSIMEPIR SIIRGKKAEA KFVEAEVTKI DPYNRTVTVS HRAMHDNVKS EQIPDLVEEM
PYDYLVIGVG SEVSTYGIPG VQEYGCYLKE IEHAQQIRKR IMDCFEAASF PGVDPETRKR
LLTTVVVGGG PTGVEFAGEL HDFYVEDLKA LEPNLRDQVT LTLIEALPNV LPSFSKHLCD
YAEKTLLDEK INVLTKTAVK KVTSDTIYAE KTLPDGRKEE VVIPYGLFVW AGGNSARPII
KDLFSVIPEQ ATARRGLLVD EYLQVLGTDG VWAIGDCTSS HYAPTAQVAA QQGSYVGRLL
NQIAERDDTL DKVTVLKKQL DDGLTDKKVA ANELRHWERR LEKASKLKQF QYSHQGSLAY
VGSEKAVADL SFWGNAFASG GTWTFMFWRS AYLSMCFSIR NRLLVMLDWT KVRLFGRDVS
RE
//
