ID   A0A2T0ML44_9ACTN        Unreviewed;       544 AA.
AC   A0A2T0ML44;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 12.
DE   SubName: Full=Heparinase II/III-like protein {ECO:0000313|EMBL:PRX58357.1};
GN   ORFNames=B0I32_12380 {ECO:0000313|EMBL:PRX58357.1};
OS   Nonomuraea fuscirosea.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=1291556 {ECO:0000313|EMBL:PRX58357.1, ECO:0000313|Proteomes:UP000238312};
RN   [1] {ECO:0000313|EMBL:PRX58357.1, ECO:0000313|Proteomes:UP000238312}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.7104 {ECO:0000313|EMBL:PRX58357.1,
RC   ECO:0000313|Proteomes:UP000238312};
RA   Whitman W.;
RT   "Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the genomes of
RT   soil and plant-associated and newly described type strains.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000256|ARBA:ARBA00004418}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PRX58357.1}.
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DR   EMBL; PVNG01000023; PRX58357.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2T0ML44; -.
DR   Proteomes; UP000238312; Unassembled WGS sequence.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.70; -; 1.
DR   Gene3D; 1.50.10.100; Chondroitin AC/alginate lyase; 1.
DR   InterPro; IPR008929; Chondroitin_lyas.
DR   InterPro; IPR012480; Hepar_II_III.
DR   InterPro; IPR031680; Hepar_II_III_N.
DR   PANTHER; PTHR39210; HEPARIN-SULFATE LYASE; 1.
DR   PANTHER; PTHR39210:SF1; HEPARIN-SULFATE LYASE; 1.
DR   Pfam; PF07940; Hepar_II_III; 1.
DR   Pfam; PF16889; Hepar_II_III_N; 1.
DR   SUPFAM; SSF48230; Chondroitin AC/alginate lyase; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Periplasm {ECO:0000256|ARBA:ARBA00022764};
KW   Reference proteome {ECO:0000313|Proteomes:UP000238312};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..544
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015506081"
FT   DOMAIN          56..287
FT                   /note="Heparin-sulfate lyase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16889"
SQ   SEQUENCE   544 AA;  59692 MW;  9BD04A0AE66968CE CRC64;
     MRRLAIPLAL MLSVGALGSP AQATDKVTRT AECQGDWLPG TPTANDVMKG EISLVGLPAY
     KLGKDIKWAA SPFKNRSWEF VFQSLRWMGT LVVEYENTGE RQYLDRATDI AKDWVASNRY
     GAKGTPSYVW KDHPVSLRTQ PLLCLSRHVN AGWLKESLAA HAKLLSNPRL YKKGHNHGID
     QDIALMGIGC RYARKDWANL ASRRLTGTVK LDVDAQGALM EQAPRYAVYV YGRLQVAMTN
     MKACGRKVPG EISRRAEALK DFIAHSTLPN GYMVPIGDGS AETEPKMETG TPKQKVKTYR
     AGYVFGRTKW GEPDSAYYSI RYGPGMKFHG HEDHLGVTYY AQGRDILMDG GFHSYEKSSY
     RYWTLSPEAH NVPTVVGARF RPRTSSKLIK SSYGDDRQAF KLTDKAYGVS RTRSVLVNHG
     EDLMAVLDTA SGGKKVSSIW RFAPSFKVVS NGGGKVVLAD GKFKVTLLQY SASCGRTGGQ
     KVERGGKLGW VSPTYLSKQP ASVVKSPAAK SLLTIIVPGT DSPKVSCSGG KVKVDGVSFS
     TRLL
//