ID A0A2T0MU30_9ACTN Unreviewed; 663 AA.
AC A0A2T0MU30;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=RND family efflux transporter MFP subunit {ECO:0000313|EMBL:PRX62206.1};
GN ORFNames=B0I32_113159 {ECO:0000313|EMBL:PRX62206.1};
OS Nonomuraea fuscirosea.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Nonomuraea.
OX NCBI_TaxID=1291556 {ECO:0000313|EMBL:PRX62206.1, ECO:0000313|Proteomes:UP000238312};
RN [1] {ECO:0000313|EMBL:PRX62206.1, ECO:0000313|Proteomes:UP000238312}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.7104 {ECO:0000313|EMBL:PRX62206.1,
RC ECO:0000313|Proteomes:UP000238312};
RA Whitman W.;
RT "Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the genomes of
RT soil and plant-associated and newly described type strains.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRX62206.1}.
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DR EMBL; PVNG01000013; PRX62206.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T0MU30; -.
DR OrthoDB; 3286702at2; -.
DR Proteomes; UP000238312; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR32347; EFFLUX SYSTEM COMPONENT YKNX-RELATED; 1.
DR PANTHER; PTHR32347:SF14; EFFLUX SYSTEM COMPONENT YKNX-RELATED; 1.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000238312};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..663
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015679848"
FT DOMAIN 63..107
FT /note="Membrane fusion protein biotin-lipoyl like"
FT /evidence="ECO:0000259|Pfam:PF13533"
FT DOMAIN 462..560
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 113..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..266
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..336
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 663 AA; 64661 MW; 7C203B8B9513CF3A CRC64;
MRRTFALGGL ALAVLVAGSG LALALRDDTP PAVRVRLAAA QRGQVTAAVS AAGDTVDGSR
RELAFGSSGT LTKVSVKVGA KVKKGQVLAR IDGRAAREAY TAAKADLAAA EEARDEAAAA
PTTGGGDRTP ATCVPTAGPG KNATTPASTG RATPVPTGAT PIPTGTTPVP TGATPAPSGG
STTSVPTNGS ADRAVNGPAD GPVDVTGNGP VDVAAGTARG AGGGYGPEEP YGAKADPGAG
PARGRSPHPT PKPTPTPTPD PTEPEPRPTV TVTVTETVTA TATATVTATV TTRPTGGSSD
GGTEHPGSHP SMTAAPPDRP ATTTPTGPPA GPPTSAKPST KKPTATGKPT GGTKPSATGK
PTRGGKPSTG SGHPSQGSCG GTGAAGTTKA AGTTGTGDTG TGDTETRTTG TGAAGTGTTG
TGSTGTGATY ADTTGAEGSA GSQAKGGLSE EQAAVEVERA EAALQQAADA VRATRIVAPA
AGTVLSVAGG TGDRAGTGTF ISLGDLDELQ VQAMVTESDV GRLKLGQKAV VTLATRGDER
HEGTVTAIAP TATVDGRLVR YPVTVAFDDP PTGLMLGQTT SVTITTDQAS DTIYVPAAAV
RSRSDGTQVV TVRSGDQDTA KVVRTGVRGD QYVEVVSGLV ESDQVVLSDG TSGEFPEGNW
PGT
//
