ID   A0A2T0N135_9ACTN        Unreviewed;       633 AA.
AC   A0A2T0N135;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Succinate dehydrogenase / fumarate reductase flavoprotein subunit {ECO:0000313|EMBL:PRX65490.1};
GN   ORFNames=B0I32_107252 {ECO:0000313|EMBL:PRX65490.1};
OS   Nonomuraea fuscirosea.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=1291556 {ECO:0000313|EMBL:PRX65490.1, ECO:0000313|Proteomes:UP000238312};
RN   [1] {ECO:0000313|EMBL:PRX65490.1, ECO:0000313|Proteomes:UP000238312}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.7104 {ECO:0000313|EMBL:PRX65490.1,
RC   ECO:0000313|Proteomes:UP000238312};
RA   Whitman W.;
RT   "Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the genomes of
RT   soil and plant-associated and newly described type strains.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PRX65490.1}.
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DR   EMBL; PVNG01000007; PRX65490.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2T0N135; -.
DR   Proteomes; UP000238312; Unassembled WGS sequence.
DR   GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   Gene3D; 1.20.58.100; Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain; 1.
DR   Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR   InterPro; IPR003953; FAD-binding_2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR037099; Fum_R/Succ_DH_flav-like_C_sf.
DR   InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
DR   InterPro; IPR030664; SdhA/FrdA/AprA.
DR   InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR   PANTHER; PTHR11632; SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT; 1.
DR   PANTHER; PTHR11632:SF89; SUCCINATE DEHYDROGENASE [IRON-SULFUR SUBUNIT] (SUCCINIC DEHYDROGENASE)-RELATED; 1.
DR   Pfam; PF00890; FAD_binding_2; 1.
DR   Pfam; PF02910; Succ_DH_flav_C; 1.
DR   PIRSF; PIRSF000171; SDHA_APRA_LASPO; 1.
DR   PRINTS; PR00368; FADPNR.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF46977; Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain; 1.
DR   SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE   4: Predicted;
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000238312}.
FT   DOMAIN          13..432
FT                   /note="FAD-dependent oxidoreductase 2 FAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF00890"
FT   DOMAIN          486..595
FT                   /note="Fumarate reductase/succinate dehydrogenase
FT                   flavoprotein-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02910"
FT   ACT_SITE        325
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000171-1"
SQ   SEQUENCE   633 AA;  69582 MW;  B7EA11689D5E16FC CRC64;
     MENTHNIERH EYDVIVIGAG GAGLRAAIEA RQQGKRTAII CKSLFGKAHT VMAEGGAAAA
     MGNVNSDDNW MVHFRDTMRG GKFLNNWRMA ELHAKEAPDR VWELEAWGAL FDRTKDGKIS
     QRNFGGHEYP RLAHVGDRTG LELIRTLQQR VVALQQEDYE THGDYEAYIK VFAECTVTRL
     LKDGDAISGA FGYWRETGNF VLFDAPAVVL ATGGIGKSYV VTSNSWEYTG DGHALALLAG
     ANLINMEFIQ FHPTGMVWPP SVRGILVTES VRGDGGVLRN SEGKRFMFDY IPEVFKDKYA
     TTEEEGDRWY TDQANNRRPP ELLPRDEVAR AINAEVKAGR GSPQGGVFLD VSTRLPAEEI
     KRRLPSMHHQ FKELADVDIT AEPMQVGPTC HYIMGGVEVD ADSGAAAVPG LFAAGEVSGG
     MHGSNRLGGN SLSDLLVFGR RAGAGAAAYV DGLAARPKVE SELVDAALEE ALAPLNRSGE
     NPYEVHHELQ RTMNELVGII RKAEEVSEAL EAVEKLKERV RMVGAAGSRI YNPGWHLAID
     LRNMVLVSEC VARAALLREE SRGGHTRDDF PGMNPGWRRK LLVCSTADGA SVQVEEKLQP
     SMRDDLITLF DRDELSKYLT DEEMAEFDGI AKS
//