ID A0A2T0N5S1_9ACTN Unreviewed; 1375 AA.
AC A0A2T0N5S1;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:PRX67710.1};
GN ORFNames=B0I32_104467 {ECO:0000313|EMBL:PRX67710.1};
OS Nonomuraea fuscirosea.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Nonomuraea.
OX NCBI_TaxID=1291556 {ECO:0000313|EMBL:PRX67710.1, ECO:0000313|Proteomes:UP000238312};
RN [1] {ECO:0000313|EMBL:PRX67710.1, ECO:0000313|Proteomes:UP000238312}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.7104 {ECO:0000313|EMBL:PRX67710.1,
RC ECO:0000313|Proteomes:UP000238312};
RA Whitman W.;
RT "Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the genomes of
RT soil and plant-associated and newly described type strains.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRX67710.1}.
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DR EMBL; PVNG01000004; PRX67710.1; -; Genomic_DNA.
DR OrthoDB; 3671989at2; -.
DR Proteomes; UP000238312; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000238312}.
FT DOMAIN 1027..1102
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 579..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 934..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..604
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1375 AA; 147292 MW; 263D9C9AB6C8CAFC CRC64;
MTVTTGAARG LEDAYPLAAL QAGMLYHSAY EPDAATYHDL TTITLRGMFD AGAFEAALAE
VTARHPVLRT SIDLTGFSEP LQLVHRSATL PLEVTDLAGF SGDPEEAGRR LAEWSEAEKR
RPFDWASPPL ARAHVHVLPG ELFAFSLSFH HAILDGWSVA ALVTELLQRY HGHLTGEPVP
LTRPGAAFRE LVAAERAAVA APETRDFWQA RMAGAPGTRL PRLPGPHGEP GAEVLRLPLP
AELLERLGGA ARGLAVPLRT LLLAAHLRVL ALVTGESEVM TGLVTHSRPE SEAGEEVLGL
FLNTVPLRLD VTAPTWAELV REVFEAEVAL LPHRRYPLFE IQRAAGRSPL LDVLFDFRDF
HVYRGLPGVE IVDQDFFEQT DVPFAAAFGR SREHGGFDLT LTYDRAQFDA GQVARFGELY
LVALHQAADP GDDPRSEGPY LERDAAAIDG WNATARTYPD AALHELIAAQ AARTPAAPAV
CYDGTWLSYR ELTERAGAVT ARLTAAGTRP GDVVGVCLER GPDLLPALLG VLGAGAAYLP
LEPGLPTERL AYMIEDARAR TVLTGAASTT VLPAGVALPL TGPEPDPAAL PRTGPEPDPA
ALPRTGPAAG PVAATGLALE PAADSPDVPG SPARVHPDSP AYVIFTSGST GRPKGVGVSH
RAIVNRLLWM QEAFGLAPDE RVLHKTPLSF DVSVWELFWP LITGAGLVVA EPDAHRDGAR
LAALAAAHDV TTMHFVPSML ELFLDEPDLP ALRRVICSGE ALGAELAARC HDRLPHTELH
NLYGPTEAAV DVTWHPYEPG EPSVPIGRPV ANTRLEVLDA GGRRVPVGTP GELCLGGVQL
ARGYVSRPGL TAERFVPDPY GPPGARLYRT GDLARWLPTG EIQYLGRTDF QVKIRGQRVE
LGEIEALLTA EASVRAAVVV LRGERLVAYV VPENGSANGS ENDAAGGSDA PHTDSGGSDA
PNTDAAGPAA PAGRLPDLAA ALRTRLPEYM IPAAWVPLDA LPVTANGKLD RAALPDPGDA
GRAPYLPPRD PFEARLATLW EETLGVDAIG VHDDFFALGG HSLLALRLTM RLRKELGRDV
PLSSVLTAPT VAGLAAELRR PQDNDGAPRR IVPLRPTGDR DPVFLFHALG GQVFRYLPLT
RHLGPDQPVY AVQAAGLAPG ERPHATLAEM VDDYTAHLLE VRPHGPYVLG GYCIGGNIAL
ETARRLRELG EEVPLVVLFY SDANEPVLRA SLEDDAVLLT HALAGGKVQV NLDDLHRMSP
DERLLAVIDA AARADTLQPD TADLRQARRF VDVFRANAHA VGHYRHDPYD GDVLLYSPAA
EGVPPDDMGW RDVVTGRLRI SPIHGERFTV MYEPRVALAA AELRSSIDHG LTSDD
//
