ID   A0A2T0N7Q7_9ACTN        Unreviewed;      3748 AA.
AC   A0A2T0N7Q7;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Non-ribosomal peptide synthase protein (TIGR01720 family)/amino acid adenylation domain-containing protein {ECO:0000313|EMBL:PRX68616.1};
GN   ORFNames=B0I32_103578 {ECO:0000313|EMBL:PRX68616.1};
OS   Nonomuraea fuscirosea.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=1291556 {ECO:0000313|EMBL:PRX68616.1, ECO:0000313|Proteomes:UP000238312};
RN   [1] {ECO:0000313|EMBL:PRX68616.1, ECO:0000313|Proteomes:UP000238312}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.7104 {ECO:0000313|EMBL:PRX68616.1,
RC   ECO:0000313|Proteomes:UP000238312};
RA   Whitman W.;
RT   "Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the genomes of
RT   soil and plant-associated and newly described type strains.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PRX68616.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; PVNG01000003; PRX68616.1; -; Genomic_DNA.
DR   Proteomes; UP000238312; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 1.
DR   CDD; cd17646; A_NRPS_AB3403-like; 1.
DR   CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR   Gene3D; 3.30.300.30; -; 3.
DR   Gene3D; 3.40.50.980; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 4.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR010060; NRPS_synth.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR   NCBIfam; TIGR01720; NRPS-para261; 1.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 3.
DR   Pfam; PF13193; AMP-binding_C; 3.
DR   Pfam; PF00668; Condensation; 4.
DR   Pfam; PF00550; PP-binding; 3.
DR   SMART; SM00823; PKS_PP; 3.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR   SUPFAM; SSF47336; ACP-like; 3.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 8.
DR   PROSITE; PS00455; AMP_BINDING; 3.
DR   PROSITE; PS50075; CARRIER; 3.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000238312}.
FT   DOMAIN          642..716
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2221..2295
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          3671..3748
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          896..917
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1753..1788
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2157..2189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1765..1779
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2164..2189
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3748 AA;  400219 MW;  0CA6CA4B91FBACF8 CRC64;
     MEASPRLVSL SPARLAGVRR RTGDRSDRTI TLACAAGLAY WATGQSPDRL DLTPATPFAD
     VLDWAGDHER VAGWEVGADG RSIVVPGGVD PAEAQLALDD LADFPDRPVG TVGPSSVAAR
     LETLARWNDT RADRERPTIV EMFREQARTR PDAVAIVDER RSLTYREAAA LSNQLAHHLI
     ERGLTAEQIV GVSLDRSAEM VLGLLAVLQA GGAFVPLDPR WPAARRAVVI ADAGVVLQLD
     GSGAGAAGEP EAVAVDLDAW RFGAYPTGDT GGDIPGPALA YVIFTSGSTG RPKGAMIRHE
     AISERLLWQS REILGFGHDD ASLFKAPLSF DISINEIFLP LVCGGRLVVL RPGGERDPHH
     LLSVIAGQRV TFTYLVSSML DVLLEIEGGS GRLDSLRHVW CGGEVLTPDL YERFRTRLGI
     PMYHGYGPAE TTIGVSHVIY RGAAERLSTS IGRANPNTQL YVLDDELRPV PFGVGGELYA
     GGFLLGRGYV NAPGLTASRF VANPFAGDGS RLYRTGDLAR FAPDGSLDFL GRADNQVKIR
     GMRLEIEDVE IGLAEHPRVR HTCVVARKNA AGGTYLVGYV IPVSGDGGLS PDEVRAWAAE
     HLVEYMVPAH VVVLKEFPLT ANGKLDRAAL PEPELRTGSA AAPATENERV VCAAVASVLR
     LEEVGPDQNF FRLGGDSLMA ISLMSALRDA GLHVTATQIF TNLTVGALAA VAVPAEAASA
     DLQDVPTGPF AGTPIVRWLA GTTDAIDGFV QSVVLNTPDG LTADALGELL TALVRRHDML
     RARLVRDEPW GFHVPEPDTA VASWEESDRP LDECVELATA GLSPDDGVML RAVWRRASRQ
     LVLAAHHVVI DGVSWRVLMD DLATGWRQLA SGTPVEPPPV GTSFRRWAQL LERAASEADP
     GHFQRPLPGP DRPLGRRPLT GSDVVARERV RTVTAGPDVT AALLGEVPAR FHAGVGDVLL
     TALAVALARW RRDLGQEQTF AHIELEGHGR EARFVAGAAG FEPDLSRTVG WFTTLFPVTV
     DPGAAADLTG PAYLSAALKA VKEDLARVPD NGISYGALRY LAGVAFDAPA PQVLFNYLGR
     YDAGTPGDWQ LAGATGQLGE KRDPKMRLPR ALEFNAIAEP GATGAYELVT SISWPDGLFT
     DEDVATIGGY FLRALTGLAA LDTGGHSPSD FAAVTLTQAD VDALDGPALL DVLPLTPLQE
     GLYFHSVFDD DSAGSYVEQQ ILMLDGEVDA GRLAAAATRL LALHPNLAAR FVALADGRVV
     SVLESGVTAP FRTLDRPGIT GDELRDLAER DRRAGFDLAA GPLTRYTLVR TGPGRSVLVQ
     TVHHIVADGW SVPPMLRALL AEYHAPGSVH VRDGFAGHVR ALAARDGDES DRVWREQLAG
     LPGPSLVAEG HTPSGRFAET GVSGEDLAAL DGDVDAAARA AGVPLSVAVH SAWAVTLGGI
     LQGRDVVFGS TVSGRDADVP GIKDMVGLLI NTIPVRVRWS NDTTARDLLA SVREHQSAVL
     EHQHVSLTRI GRLAGSGTLF DTLVVFDVPT DVASLRRPGD EFVISDLVNE GAPHYPLTLV
     VEREAGGRAR FNLIYDGELL RESRARAVLL TFTRTLTGLL TRPDSPVTAA VNADGVITPV
     TLGGLFDAAA RRDPAATAVT QCALDGGTRS MTYGELAAAK DELAMALRAA GVRPGERVAV
     AVPRSLEQVV ALIAVVSAGG AYVPLDLAYP DERLAYVLAD AAPKVVLVDG TERERFTELA
     TRAGVPARVL TLDGEVSLPG QEGEQPPDGR DRGAPSDARD GEVPSDTAAA MAEADWNDPA
     YVIYTSGSTG RPKGVVVPHS SVVALLAGTQ PDMGFGPDDV WVQFHSFSFD FAVWELWGAL
     AYGGELLLAE YALTRSPLDF HRLVRERGVT VLNQTPSAFY QFAEADRHAG RPVTSLRRII
     FGGEALDLGR LRGWVERYGT ASPELVNMYG ITETTVHVTH RVLTGDDFTA GDVSPIGGPI
     PGLTTYLLDD RLRPVPPGRV GGIYVAGDQV SLGYLGRPGL TASRFVADPF AGDGSRMYHT
     GDLARRTIDG ELEFVGRADD QVQLKGFRIE LGEVESAIRG LDGVVDVAVT VAAGGGHLVA
     HVVGQVSDDL TGPLSAKLPA HMVPGRVLHV DALPLTVNGK LDRTALTERA TALDDAPTYA
     TGDSWDSPPA TLVNDRPTST PDTTRSRLDQ TASTLDGSAF VHDRRASALG RTSSAHERPV
     PAGDGALAAL VKVFGEALSG VDADADTDFF VAGGDSIVAI TVVNRARALG LPITPRDVFL
     LRTPRALAAH VRTHAPPVTA PVRHEDGPLT PTPIILRQRE LGGSLARFAQ ARTLVAPEGT
     RFEDVERAAN AVVAAHPMLR LRLRTEHGVW TLRTDPPHRI TVTRPEAVTD PAALADELAG
     RLDPEAGEVV AFAWLAASRT LVIAVHHLAV DAVSWLILLD DLATALRGTP LTPPTTSYAE
     YADALATEAT QAQAVGTLDR WITTLQAPPL LSKATGEPTT LCETTVELPP ELTTAVARTA
     PVALGLGLTE LLCGALRAAL TRVQAAPTDL AIELERHGRV PAGDRHDYAR TVGWFTSIAP
     VRLTPHTDPV AAARELTERQ PDEADHVAYG RLRYLNPQTA PLLRARPQVL FNYLGRATES
     QALHITGGDQ GSPYAVEVNA WIDAGTGTLR AAFTLADAVP DELTAYWRQA LEQVAEAAAT
     AERTAPVTPL QRGLFFQAQL AGSAGHYVAQ NYFTFDRRLD PGALAEAMAY VIARHPVVGA
     GFATDAAGNP VQVLAAGRRV GVRTIALSTD AEVEALCARD RDTGFDPGEP PLIRLTVVRR
     PDGRDGLLLS YHLLLWDGWS REIVLRDLFD AYETALADEP PTSGPVGEPL GPVPAAPSFE
     EYARALDARD PDPSRRFWAE HLAGLPGPTL LAGPAPVLSD ALPRALVHTL SAEQSDLLRE
     AARTHAVTLN SLLTGAFGLL LGAHTGRGDA VFGVTVSGRE GAGLDGIVGV LLNTVPMWTR
     PRPYETVGEY LSGVQAARVA AMEHEHLGLG EIQRAGGHDT LFDNLFVLQN FLDLDALAAM
     NARHGITSVR ADDSTHYPFT WVITPGERFT IKLEYRDDDP ERARALLDDY LRVLGEVARA
     TGPVGGLPGF GPEPERAPRT EVGTDTVVDR FDRAAERSPG RVALVADGRT MTFGQLQERS
     RAVAGVLAAR GLGPDRTVGL AIPRSLDSIV ALFAVLRVGA AYVPLELDHP DERIAAIVAD
     ARPDVILTVS AVSPRLTGAA GGGEPIEPDR PRPRADLIEL DRPLPEAEPV ATFAPDDPGR
     LRHPAYVIYT SGSTGRPKGV VTEYAGLTNM LINHQRRIFE PVLAEHGHRI FRIAHTVSFA
     FDMSWEELLW LADGHEVHIC DEELRRDAPR LVEYCLRHTI DVVNVTPTYA QQLVAEGLLD
     DPGRRPPLVL LGGEAVTPGL WRRLDETEGT VGYNLYGPTE YTINTLGVGT FECQDPVVGV
     PIDNTDVYVL DPWLRPVPDG VPGELYVSGV GIARGYLGQP GQTAHRFVAC PYGEPGERMY
     RTGDLVLRRP DGNLAYLGRT DQQVKIRGHR VEPGEVEAAF TAHPAVRFAA AVAQPDPQVD
     GAYRLAAYLV LDGADLARVA AEVGAGLPDF LRPTHYAEVA AIPLTVNGKA DVKALPEAKP
     LGALSTAGER RPATENEILV CEFFAEALDL DDDEVSAVSD FLSLGGHSML AVRLVGLLRR
     EYGPRITIRD LYALRTPEAI ARHLDDHS
//