ID A0A2T0PYJ4_9ACTN Unreviewed; 1513 AA.
AC A0A2T0PYJ4;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:PRX96529.1};
GN ORFNames=CLV72_10752 {ECO:0000313|EMBL:PRX96529.1};
OS Allonocardiopsis opalescens.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Allonocardiopsis.
OX NCBI_TaxID=1144618 {ECO:0000313|EMBL:PRX96529.1, ECO:0000313|Proteomes:UP000237846};
RN [1] {ECO:0000313|EMBL:PRX96529.1, ECO:0000313|Proteomes:UP000237846}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45601 {ECO:0000313|EMBL:PRX96529.1,
RC ECO:0000313|Proteomes:UP000237846};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRX96529.1}.
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DR EMBL; PVZC01000007; PRX96529.1; -; Genomic_DNA.
DR Proteomes; UP000237846; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 1.
DR PIRSF; PIRSF001617; Alpha-AR; 4.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000237846}.
FT DOMAIN 1395..1470
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1367..1399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1513 AA; 157499 MW; AC5C25C638814576 CRC64;
MRIPLERGPG DSSAPASSTQ ERFWFAERLR PGTAVHNLAF GARVDGALDA AAVREALREI
VRRHSVLRTR LVLDGDRLLQ VTSTVPDTPL AVREAGSAGQ ADALVRSFAT EPFELSRGPL
FRAALIRAPG EQERLVLVAH HAVFDGWSLG VFFTEFAALY RAATGQGPAA PPPALQYADY
ARWQRARAEA REPAGQYAFW ERALAEEVEP LEPPLDHPRA PVPRFLGGHR AVTVDGPAAR
RLSALAAEES ATLYMAVLAA FQVLLYRHTG RRRFHVGTPT ANRPDERLHA LIGPFVNVLP
VRADLTGDPS FRELLVRTAR TVTDVLDHQE VPLQALAGRP ARPGGPAAPL FRTAVAFQNF
PAVPLDLGAG TALLPFPVET GTAQDDLALF VSPGAAGLDA VLRYDADLLR ADTVAELAAD
LSGLLRRLAR DPELPISRLA AAGVPVPRRV DRAQPVPPTP PQRRLHAARA AGAAPERRIA
TAPLPADASA EAVGAALGWV EERYEALRTV LVDDGGPLRQ VVGPPGRARL RRLDPLAAGT
GAGGLAAALA AGAGPDEPLA VGLARSPGAS LLIAAADPLA LDAWSLRRVM DALVRGYHAA
AAGGSPGDGA DPPLQAADHA VWLRRAVGGA DGRARAAYWR ERLAGMPARL PLAGAQDGPG
PGRWVTAAVA APVPAPAGPA GAADDALLAG AAVALSRFGA GRDVVMATPA AGRTGGGQRA
VVGALADVVP VRIAVREDES AAELIARVHA ERTRDSAAEL PFDTIAAGLD GPCEALRQVL
VLGPGDGSAQ DWEPDADALG TALVLAVGDG GAALRYRTDR YLAAAAEELA AVLAHLLECF
AADPHRPVGE AESLPDERRL RILAAADATG AAGPDTTLLD QFERRAAEAP EADAVIDGAT
VLSYREVAAR AARLAGRLTE LGAVPGRPVA VLMDAGAAAI VALLGVVKAG AAFACVDPVN
PGARVRGLID ELRPALVVAD AAAAGRHAGA LAGAAPVAVV DAGGGAEPSS VPGVPPRGAA
APRPVAAPVP RDLAYIAYTS GSTGRPKGIP HTHADLAEFV RWQADALGIG PGQRVGQLAA
LSFDVAYCEI FGALCSGAAL CMRPAGGRAD PGALARWLRE RRVTVLQVIP RLFREVLRRL
RSDGGGTALR TVAFVGEPLP ADVVAAARAV LGAGVRMVNI YGPTEAVAAT SFTVDAVPPD
GAAVPIGRPI DGRAVLVLDD QGRLCPAGVT GELWIAGPYL SAGYLGDPDD TAARFAASVR
ARPRGRAYRT GDLARLRHDG ELEFVGRTDN QVKLMGVRVE LEEVERAAAR FPGVRECAAA
VQEAGQGQHL VLYVVADPAH DTAALRDFLA ERLPRTMVPG VVVRPAALPR TPNGKLDRRA
LPPAGERTSA RGSAPPRTGL ERDLAELVGE VLGAAEVGRD DDFFQLGGNS LQAARLVNRI
RERHGADVPL QDLFARPTVA GTAAEVERRL AEAGLDGRLA GIEERLAGLT DDEVEALLAE
YEAPPDADES RAM
//
