ID A0A2T0QDG8_9ACTN Unreviewed; 1133 AA.
AC A0A2T0QDG8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=CLV72_101594 {ECO:0000313|EMBL:PRY01996.1};
OS Allonocardiopsis opalescens.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Allonocardiopsis.
OX NCBI_TaxID=1144618 {ECO:0000313|EMBL:PRY01996.1, ECO:0000313|Proteomes:UP000237846};
RN [1] {ECO:0000313|EMBL:PRY01996.1, ECO:0000313|Proteomes:UP000237846}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45601 {ECO:0000313|EMBL:PRY01996.1,
RC ECO:0000313|Proteomes:UP000237846};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRY01996.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; PVZC01000001; PRY01996.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T0QDG8; -.
DR Proteomes; UP000237846; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000237846}.
FT DOMAIN 21..354
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 355..689
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 42..49
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1133 AA; 121301 MW; E05CC8C2CDA86435 CRC64;
MTGAEPVRFG PVQLARLLGL PEPTAEQAAV IGAPLRPGVV VAGAGSGKSE TMAARVVWLV
ANGLVRPEQV LGLTFTRKAA AELAHRVRTR LDQLKAAKVL PPTPSGEEGS PDVLDGEPTV
STYHAYAGRL VADHALREAV EPSARLITPA VEWQLASRVV ADYDGPMDAV PWAPATVTSG
VLELGGELAE HLRDGGEVRE LGDRLRAEAD ALPGRVPAAT AALLRAQRAR EQLLPMIERY
AKAKAAREVM DHGDRVALAA RIARGHAEVG RIERERFQVV LLDEYQDTSH AQLVLLRALF
GGGHPVTAVG DPCQSIYGWR GASAGNLLRF PGDFPAADGE PAPVGQLATS FRNGERVLDV
AKVLAEDLRA EAAAVPVLHP GGARRGRGAV ACALFATADD EAEWIAAQIA AALDLPGGIA
PDGRPWTDER DEGRRVRPAD VAVLCRKRGQ FAPIRAALRR RGIPVEVVGL GGLLTVPEVS
DIVATLRMLH DAGAGDALAR LLTGPRWRLG PRDLVALGNR ARELARQARR DLDGARLPEP
VDEPDPLRQA VADMTAEVGS LIDALDDPGD AEGYSEAGYD RLLRLGAELR MLRRQAAQPL
PDLINEVERV LGLDIEVAAR PGREPVSARA DLDALVDAAS RFAGSTEDPT LGAFLAYLAA
AQDQEFGLEA GRVGESDSVK LMTVHAAKGL QWPLVVVPGL SSGRRGTVFP ARPRTSTRWN
DNPRKLPFPL RGDAGDLPVL AGVDADALAE FTEACALRDQ REERRLAYVA VTRASFGLLC
SGYWWGDGAA RLGPSVFLDE VRAACLAGAG RVVRWEAPPG EDAENPRLAE PKRAPWPAAP
GGAVHAGVVE GADLVRSAGW PLPHVGAAGG ADGGEVRAAT AGELWLDRIG RATLPPGMRR
RLDGWERDVE LLLAHREAQR DRDGVQLVEL PGHLSVSSLV TLARDPEELA RQIRRPMPRP
PAPYARRGTA FHRWLETRFG QQELLEPDQL PGAADDGAAD DGELAELREA FERGAWASRV
PIEVEVPFET MLGDRLVRGR IDAVFAETGD DGQARFDVVD WKTGPMPATG AERRAVSVQL
AAYRLAWADL ARVPVERVGA AFHYVRFDTT VRPSDLLDGA ALRALLEELP AAE
//