ID A0A2T0SN85_9PSEU Unreviewed; 1076 AA.
AC A0A2T0SN85;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Acyl transferase domain-containing protein {ECO:0000313|EMBL:PRY34880.1};
GN ORFNames=CLV43_115156 {ECO:0000313|EMBL:PRY34880.1};
OS Umezawaea tangerina.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Umezawaea.
OX NCBI_TaxID=84725 {ECO:0000313|EMBL:PRY34880.1, ECO:0000313|Proteomes:UP000239494};
RN [1] {ECO:0000313|EMBL:PRY34880.1, ECO:0000313|Proteomes:UP000239494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44720 {ECO:0000313|EMBL:PRY34880.1,
RC ECO:0000313|Proteomes:UP000239494};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRY34880.1}.
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DR EMBL; PVTF01000015; PRY34880.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T0SN85; -.
DR Proteomes; UP000239494; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 6.10.140.1830; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF18369; PKS_DE; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000239494};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:PRY34880.1}.
FT DOMAIN 33..456
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 991..1066
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1076 AA; 112621 MW; 8374E8385D458315 CRC64;
MTDEDRLVDY LKRVTAELHR TRRKLHDLED AEPEPIAVVG LGCRFPGGVR TPEDLWRLVA
DGGDAIGAFP TDRGWDLAGL YDPDPDQPGT CYATEGGFLY DVDRFDPAFF GLGPREATAM
DPQQRQLLEV AWETFEHAGV DPHSLRGSRT GVFAGVMYGD YATRLGSAPP EYEAFLGSGS
ATSVVSGRVA YTFGLEGPAL TVDTACSSSL VTLHLAARSL RDGESDLALA GGVTVLASPS
VFTDFSRQRG LAPNGRCKPF SAAADGTGFG EGVGLVLLQR LSDARRDGRR VLGLLRGSAV
NQDGASNGLT APNGPSQERV IRAALADARL SASDVQLVEA HGTGTSLGDP IEAQALLATY
GQDRSEPLRL GSVKSNIGHT QAAAGIAGVI KVVLAMDHGV MPPTLHAEIP SPHVDWTAGR
VELLTKARPW VAAGPRRAAV SSFGISGTNA HVVLEEAPVA DSPAVGTRAV VPWVVSGRTE
NAVRANAERW CRHLADRPDV DPADVAATAA ARTRFEHRAV VVAGDRDGLL RGLRAVAAGD
AAPDVVRGRA GRGRTAFLFT GQGSQRLGMG RELHEAEPVF AAALDAVMAE LDPRLPRPLL
DVLFAAPRSP DAALLDQTLY TQASLFAVEV ALYRLVEHRG LRPDHLIGHS VGELAAAHVA
GVLSLPDACA LVAGRARLMQ SVPAGGAMVA VAAGADEVLA SLPASGRVSV AAVNGPAATV
ISGDADGTAE VAAHWRRLGV KTKRLRVSHA FHSHHMDPVL AEFRDIAAGL SYGEPSVPVM
SNLTGGQATA EQLRSPDYWV DHVRQAVRFA DGVRRLADLG VDRFVEIGPG TVLSGMVRDC
LGDGPLLAPA LPGGRGEVAS VTHAVAAAHT RGADVDWSAL LGGHDRRTDL PPYAFARGRF
WLHDTGERAG PAARLWSAVD SADPTALAAV LGAGDDLLEP LRAVLPALTA WRQANAVAPV
AAEQPVDDVA GPDPAELRAR LLGLDDAEAE ALLLDLVRTR TALVLGLAAV DAVDVDTGFL
NIGMTSFTAL ELRNGVVALT GVELSAVVLM DNPTPRGLVA LLRAELVGRA DATPVL
//
