ID   A0A2T0SS71_9PSEU        Unreviewed;       976 AA.
AC   A0A2T0SS71;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:PRY36259.1};
GN   ORFNames=CLV43_112184 {ECO:0000313|EMBL:PRY36259.1};
OS   Umezawaea tangerina.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Umezawaea.
OX   NCBI_TaxID=84725 {ECO:0000313|EMBL:PRY36259.1, ECO:0000313|Proteomes:UP000239494};
RN   [1] {ECO:0000313|EMBL:PRY36259.1, ECO:0000313|Proteomes:UP000239494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44720 {ECO:0000313|EMBL:PRY36259.1,
RC   ECO:0000313|Proteomes:UP000239494};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT   (KMG-II): from individual species to whole genera.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PRY36259.1}.
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DR   EMBL; PVTF01000012; PRY36259.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2T0SS71; -.
DR   Proteomes; UP000239494; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR   Gene3D; 2.60.40.2220; -; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000239494}.
FT   DOMAIN          516..594
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   976 AA;  107858 MW;  634822BE820BFCC3 CRC64;
     MTVHDERALL EERLNRALRE RIRPALYGDS TPVELSVWHA PGEPVPVAEA LAATYEPARV
     GDAWGPPWST SWFRLAAEVP PEWEGRQVEV VVDLGFTHPG PGFQAEGLAY NASGEPVKGI
     EPRNTHLPVS GSSVLYYLEA AGNPTILDFE PFVPTPLGDK ETAGTEPLYR ILRADLAVFN
     PEVWHLVTDL QALQGLMKEL PQHEPRRHRI LHAIDRSLDL LDTQDVAGSA ASARSALVEV
     LSRRANASAH RVSAVGHAHI DSAWLWPLRE TVRKCARTFS NVTALMDDYP EFVFACSQAQ
     QYAWMKEHHP AVFERIASKV AAGRFVPVGG MWVESDTNMP GGEAMARQLV HGKRFFLDEF
     GVETEEVWLP DSFGYSAALP QLIKLSGSRW FLTQKLSWNQ INKFPHSTFW WEGIDGSRVF
     THFPPVDTYN SSLSGEELAR ASRQFAEHAV ATRSLVPFGY GDGGGGPTRE MLETAKRVAD
     LEGSPTVTIE TPAAFFQGAQ DEYPNAPVWA GELYLEKHRA TYTTQARTKQ GNRRSEHLLR
     EAELWATAAH LSFGSPYPYD ALDRLWKTVL LHQFHDILPG SSIAWVHREA EATYARVAGE
     LEGIIDSSVT ALAGEGKADL VFDAVSSTAR ATPQAAFVAP VGGVLDNGLL RITVSDNGLL
     TSVYDIGARR EVLPPGAVGN LPQLHADTPN QWDAWDIDPF YRNNRVDLVD GEVTALPDGL
     LVRRSFGKST ITQTLRLAED ARQLDIDTEV EWQEVEKLLK LAFPLDVRAE VSTAETQFGH
     LHRPIHVNTS WEAAKFEICA HRWLHVGEPG YGVALANDST YGHDVTRTTR DDGGTTTTVR
     LSLLRAPRFP DPQTDQGTHR FRHALVVGAG IAEAVAAGYR TNLPQRVVRG SREVEPLVAV
     DNPAVVVEAV KLADDRSGDV VVRLYESLGG RAHATLRTSF PVQRVVETDL LERPLADTSV
     DLELRPFQVV TLRFTR
//