ID A0A2T0T1S7_9PSEU Unreviewed; 3472 AA.
AC A0A2T0T1S7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Acyl transferase domain-containing protein {ECO:0000313|EMBL:PRY39630.1};
GN ORFNames=CLV43_107215 {ECO:0000313|EMBL:PRY39630.1};
OS Umezawaea tangerina.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Umezawaea.
OX NCBI_TaxID=84725 {ECO:0000313|EMBL:PRY39630.1, ECO:0000313|Proteomes:UP000239494};
RN [1] {ECO:0000313|EMBL:PRY39630.1, ECO:0000313|Proteomes:UP000239494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44720 {ECO:0000313|EMBL:PRY39630.1,
RC ECO:0000313|Proteomes:UP000239494};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRY39630.1}.
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DR EMBL; PVTF01000007; PRY39630.1; -; Genomic_DNA.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000239494; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 2.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 2.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF21089; PKS_DH_N; 2.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 2.
DR SMART; SM00827; PKS_AT; 2.
DR SMART; SM00826; PKS_DH; 2.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM01294; PKS_PP_betabranch; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000239494};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:PRY39630.1}.
FT DOMAIN 22..447
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1604..1679
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1698..2115
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3313..3391
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3472 AA; 360649 MW; F456F3AEAE55DA27 CRC64;
MTNDVRRPSG TGTSQDTMDS RHDPVVIVGT ACRLPGGVTT PAELWRLLVD GGDVFGPFPD
DRGWDVAGIY DPDPGKPGRT YVRRGGFLDD VAGFDADFFG ISPREAEAMH PQQRLLLEEA
WHLLERVGVD PTRVHGSAVG VFIGSENHQY GPGTANADGG AEGHLHTGTS AGVNSGRLAF
QLGLRGPAMT VDTASSGAMV ALHLAARSLR HGECKQAIVG GVAVMPTPGP FLAFSRQGAL
APDGRCKPFS ADADGTAWSE GVGLLLVERL SYAREQGHEV LAVLRGSAVN HDGASPSLTA
PSGAAQEQVI RDALADAGLR PSDVDAVEAH GTGTRVGDPV EVAALQAVYG DGRTADDPLW
IGSVKSNVGH TQGASGVVGV IKMVEALRHG VLPSTLHVAS PTPEVDWTSG VALLAEHREW
AGGDGPRRCG VSSFGISGTN AHVVLEQAPA VDPVGPTGGG PAVVPWVLSA KSAAAARTQA
ANLVSWLEER PDLGAVDVGR SLVADRTAFD HRLVVVGRDR DELVPRLRAA ADGLPAAGVV
GGADAAADGR KVVMVFAGQG SQWAGMGSAL LDTSPVFADW VTRCDKALAP FVDWSLVDVL
RGAPGAPALE GDEVVQPALW AVMISLAQMW RSLGVEPAAV VGHSQGEMAA ACVAGALSLE
DGARIVCLRS RIVARKLAGM GGLLSVTASR ARVDAMLARW DGLLSVAAVN GPANVVVAGE
LAALAELAAR CETEGVRAKR VPIDYASHSA QMEAVRDELL TGLAGLSPRT GEIPFMSTVD
PGWVDTAGLD ADYWFRNLRC TVQFEPAVRL LLESGHDLFL ESSPHPVLTI SVEDTVRDAG
AEAVSVGSLR RGDGDLDRVL TGLGVLFAAG APVDWAAVFG GAGTRVELPT YPFRHLRFWM
DASPAGTGDR GPGVGHPWLS AVVPVAGSEV VVLTGGLSVA EQPWLADHAV LGRPVFPGAG
FVELALRAGR EAGLDRIDWL DLTAPLVLPD QDTLLLQVRI DGVDGRDRRR VDIHSRPDSA
SDWTHHATGA LSAVGDEAVA GSSGVWPPVG AEQVEPASRY PRLAEAGLAV GPAFRGIRSL
WRRGGEVFAE LVLPERTRSG AFGLHPALLE TAARAWSFAT ADDAEGVPYP TSWADVVVHT
GGTSVLRVTM AATGADSTSL VATDDQGVPV VSVGAFETRP VAAETLVDVA AVPGGLFGLD
WVPARSGARE PASAPVVLGA DVLGLADVLR DNGVWAITAA GAADLPADAE PVDVLMCVPG
GDQDPASARA SADAALDVVR QCLDRNGSDR VTVVTRGAHT GEDLTAGAVW GALGAVQASH
PGRVHLVDLD APADALLLRA LAADEPRLAV RDGLLLVPVL GRVTAGRTPV DWSPDGTVLV
AGNPQGAAGR LARHLEAEHG MRYVVLYDPW DGGAVRDVVA AEQAEHPVTA VVVAPDHADG
SSWDNADLAW ALHEATLDLD LRAFVLFSSA AAVTGEAAGA EFAADAYLTS LAQQRNALGL
PSRALAWGTS ADGLTETGRA ALVRAGLPPL TDEQVVPLFD AAMTADRPVV LPMAVDLRAL
RARGDVPPLL RGLVETRSQE PEVVEPQPVA TTRFAHLPVD ERHRALADLV LAESAVVLGR
SAADRLDRTR EFRKLGFDSL SGVELRHRLV AALEVDLPTS LIYDHPTPDR LVEFLSGKLF
GDAADAGGTT AVAPADAGEP IAIVGMACRF PGGISSPEDL WQLVVSGQHV LSDFPTDRGW
DLEGLFTGAS STRSGGFLDD VAAFDSDFFG ISPREALAMD PQQRLLLETS WEALERSGIA
PSSVRGTRSG VFIGTFGSGY ASLVADRDDA QGFVMTGTTP SVLSGRLSYF LGMEGPAVTV
DTACSSSLVA LHWAEQALRT GDCSLALAGG VTVMSTADTF VEFSRQGGLS SDGRCKAFSD
SADGTGWSEG VGMLVLERLS DAERLGHRVL AVVRGSAVNQ DGASNGLTAP NGPSQQRVIK
QALANSGLSP SEVDVVEAHG TGTRLGDPIE AQALLATYGQ DRDRPLLLGS VKSNIGHSQG
AAGVAGVIKM VMAMQNELLP KTLHVTEPSS HVDWSAGAVE LLTEQVKWPA TGKPRRAAVS
SFGVSGTNAH VVLEQARATG ARPVRESTGP VPWVLSGKSA AAVREQAGNL VSWLADRPDV
RPVDVAHSLV STRSLFDHRV VVVGSGHDEL VAGLLAASAG VSAPGVVSGE RGEGERKVAF
LFPGQGSQWV GMGVALLDAS PVFAESIARC AEALAPFVGW SLVDVLRGAD GAPPLAGDDV
VQPVLWAVMV SLAAVWRSWG VVPAAVVGHS QGEIAAACVA GALSLEDGAR IVCLRSRLVA
NELSGRGGMA SVSASRADVE SRLVQWDGRL SVAAVNGPSN VVVSGEVEAL DELIAACLAE
GVRAKKVAVA YASHSAQMEQ LEGAILEGLA VLEPRSSEVP FLSTVTGDWL DTSTMDAGYW
FRNLRETVQL ETALRVLLES GHGVFVESSP HPILTVGVED TIEDAGADAV LVGSLRRDDG
GLDRVLTGLG ALFVAGVPVD WASVFGGAGV TVDLPTYAFQ HERYWPEATT GAGLTLTSVD
VAGGRGTVLS GELSIRRLPW LVDHVVAGRV FFPGTGFVEL VTRAADEVGC DRIEELTLTA
PLVLPAEGVV PVQVWLGPAD EEGRRELGVF SRADEEWVRH AGGAVVVGTK SVDTAFAAGQ
WPPRDAEPVP IEGFYEEIVD AGLAYGPMFR GLVAVWQRGD EVFAETALPE AIQDQAGAYG
LHPALFDAVL HPVFIADLGV EPGALPFSWE GVGLHATGAS SLRVRMTRTG DTVSIVAADH
AGAPVVVVES LSLRLMSGDR AAGSGGPGRD SLFAVDWTPV RPETTADLGT PVVLGPDVLG
VRAGLRAAGV SCAEAADVAA LRAGGVVPKV VVTSVVGHHD VVASTHGLAG DVLEMIQQWL
AAEELADSRL VVVSRGAVSG DDLAAAAVWG LVRSAQIENP DRFVLVDWDG GDLPLAAVLG
SGESQALLEK GEVRVGRLGR MSGVDPGPHL GWDPDGTVLV TGGTGGLGGA LARHLVVEHG
MRNLVLLSRS GPAAQGAAEL VADLEANGAS VEVAACDTAD RDDLAAALAR IPADRPLTAV
VHTAGVLDDG VVESLSRDRV SGVLRPKVDG GWHLHELTLG MPLRGFVVFS SVVGVMGNGG
QSGYGAGNAF LDGLVVTRRA SGLPGVSLAW GVWDSGTGMT GSLLDRDMAR LGRDGVGVLS
VPDGLGLFDV AVGSGAVNVV PVRWDWTALR TRLVVPWVLR GLLGVRRRAV GSGSPGAAAE
GLAGRVRGLG PEEARTAVMA VVRSEVGVVL GLGTGAGVEM GREFRKLGFD SLLGVELRNR
LGVVTGLRLP ATLVYDHPSP EAVADYILKD VTAGDPTARP GSPLDELDRL ERALNASPPE
DDEHKAIADR LEVLVLRFRQ PMRSTAARSE DEIKSSSVGE LLDLIDQEFG PA
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