ID A0A2T0TCM1_9PSEU Unreviewed; 515 AA.
AC A0A2T0TCM1;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=CLV43_103159 {ECO:0000313|EMBL:PRY43416.1};
OS Umezawaea tangerina.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Umezawaea.
OX NCBI_TaxID=84725 {ECO:0000313|EMBL:PRY43416.1, ECO:0000313|Proteomes:UP000239494};
RN [1] {ECO:0000313|EMBL:PRY43416.1, ECO:0000313|Proteomes:UP000239494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44720 {ECO:0000313|EMBL:PRY43416.1,
RC ECO:0000313|Proteomes:UP000239494};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRY43416.1}.
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DR EMBL; PVTF01000003; PRY43416.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T0TCM1; -.
DR Proteomes; UP000239494; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:PRY43416.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000239494};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:PRY43416.1}.
FT DOMAIN 15..208
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 257..487
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 515 AA; 53899 MW; 54F784BD0AAAFEAB CRC64;
MGSALMTRAR KTPGRVAFVG SGPGDTGLLT VRAHDLLARA ELVVADPDVP SDIVALVPEG
VEVRPAVGEP ADVAKDLVAE AKNGHTVVRL VAGDPLTLDS VVKEAQAVSR TSIAFDVVPG
VPAGTAVPAY AGVALGAVHT EVDVRGTVDW AGLAAAPGTL VLHASGSHLA EAASSLVEHG
VAPQTPVAVT VDGTGFGQRT IDTTLASLAS DAGDLSGPLV VTVGAAVAGR ARLSWWESRA
LYGWRVLVPR TKEQAGAMSD RLHSHGAIPV EVPTISVEPP RSPAQMERSV KGLVDGRYQW
VVFTSTNAVR AVWEKFREFG LDARAFSGVK IACVGESTAA KVRSFGIIPE LVPSGEQSSE
GLLNDFPPYD DILDPVDRVL LPRADIATET LAAGLRDRGW EIDDVTAYRT VRAAPPPADT
REMIKSGGFD AVCFTSSSTV RNLVGIAGKP HARTLVACIG PQTAETAREF GLRVDVQPEE
ANVPALVDAL AQHAARLRAE GALPPPRKTK RLRRS
//
