ID A0A2T0VAM1_9MICO Unreviewed; 823 AA.
AC A0A2T0VAM1;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=HAD superfamily hydrolase (TIGR01490 family) {ECO:0000313|EMBL:PRY67118.1};
GN ORFNames=B0I08_10711 {ECO:0000313|EMBL:PRY67118.1};
OS Glaciihabitans tibetensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Glaciihabitans.
OX NCBI_TaxID=1266600 {ECO:0000313|EMBL:PRY67118.1, ECO:0000313|Proteomes:UP000237983};
RN [1] {ECO:0000313|EMBL:PRY67118.1, ECO:0000313|Proteomes:UP000237983}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.12484 {ECO:0000313|EMBL:PRY67118.1,
RC ECO:0000313|Proteomes:UP000237983};
RA Whitman W.;
RT "Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the genomes of
RT soil and plant-associated and newly described type strains.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the fatty acyl-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00005928}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRY67118.1}.
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DR EMBL; PVTL01000007; PRY67118.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T0VAM1; -.
DR Proteomes; UP000237983; Unassembled WGS sequence.
DR GO; GO:0080019; F:alcohol-forming very long-chain fatty acyl-CoA reductase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd09071; FAR_C; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 1.20.1440.100; SG protein - dephosphorylation function; 1.
DR InterPro; IPR026055; FAR.
DR InterPro; IPR033640; FAR_C.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR11011:SF45; FATTY ACYL-COA REDUCTASE; 1.
DR PANTHER; PTHR11011; MALE STERILITY PROTEIN 2-RELATED; 1.
DR Pfam; PF12710; HAD; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:PRY67118.1};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000237983}.
FT DOMAIN 38..354
FT /note="Thioester reductase (TE)"
FT /evidence="ECO:0000259|Pfam:PF07993"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 767..823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 823 AA; 89381 MW; 9EB4E9EA6734640B CRC64;
MSAHAAGAGG AGSAGAAGSA GSSAGITSGD LGTAHILLTG GTGFVGQAIL ERLLESHPGT
TVSLLVRTKG STSGQDRLRN LLRKPVFSVW RDRVGDAEVE RAVRERLRVV EGSLSAFPEL
PSDLDVVIHS ASTVSFDPPI DQAFETNVGG ALGLYSALAA SGSNPHVVHV STAYVGGIRK
GIVPEARLTH EVDWRAEYTA AQGARERVQM ASRQPETLRG FIHTARAKHG KEGPQAVATA
AEAARLEWVQ SRLVDYGRMR AESLGWTDVY TLTKAFAERA AEQLWPAAEG RRLSVVRPAI
IESALTHPFP GWIDGFKVAD PLILAYGRGV LPEFPGLPDS VLDVIPVDFV VNAILAVASN
PPAADPQYFH VSSGASNPLP IHRMLQNMND FFTANPMPHA EHGHVRVPTW KFPGGRRVDR
ALRGERRRVL QSRMLIERLP SNEATRARIA KLQTRLSDLE SLQNFAELYR AYVQTEIIFD
DTRTKALFRS LPEAVQADAG FDVASIDWED YLGRVHFPAI TTLTRAFAVR RPETARTAKA
LPERSDVVAV FDLEGTVVDS NIVEQYLWVR SAGLRKAAWP AEVIGLLADL PRYLAAERRD
RGEFIRVFLR RYSGMPAERL DRVVAGGYRD TLLRHTMPEA IARIQEHRAA GHRTVLVTGS
IGALVAPLAH LFDEVVAGSM HERDGILTGY LAQPPIVDEA RAAWLRHYAE QHNIDLAQSY
GYGDSHADLV WLELLGHPHA VNPDTNLSRE AQRRRWRIHN WKRGSQRAVL PAPAPAPASV
SAGLAPVGAA ESVASAEPAP TDIRLTNGPD LTADNPKGVG TAT
//
