ID   A0A2T0WC76_9RHOB        Unreviewed;       833 AA.
AC   A0A2T0WC76;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Dimethylglycine dehydrogenase {ECO:0000313|EMBL:PRY84299.1};
GN   ORFNames=CLV74_12621 {ECO:0000313|EMBL:PRY84299.1};
OS   Donghicola tyrosinivorans.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Donghicola.
OX   NCBI_TaxID=1652492 {ECO:0000313|EMBL:PRY84299.1, ECO:0000313|Proteomes:UP000238392};
RN   [1] {ECO:0000313|EMBL:PRY84299.1, ECO:0000313|Proteomes:UP000238392}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 100212 {ECO:0000313|EMBL:PRY84299.1,
RC   ECO:0000313|Proteomes:UP000238392};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT   (KMG-II): from individual species to whole genera.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the GcvT family.
CC       {ECO:0000256|ARBA:ARBA00008609}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PRY84299.1}.
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DR   EMBL; PVTQ01000026; PRY84299.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2T0WC76; -.
DR   OrthoDB; 7156675at2; -.
DR   Proteomes; UP000238392; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR032503; FAO_M.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   PANTHER; PTHR13847:SF187; DIMETHYLGLYCINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR13847; SARCOSINE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF01266; DAO; 1.
DR   Pfam; PF16350; FAO_M; 1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF103025; Folate-binding domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000238392}.
FT   DOMAIN          7..380
FT                   /note="FAD dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF01266"
FT   DOMAIN          383..437
FT                   /note="FAD dependent oxidoreductase central"
FT                   /evidence="ECO:0000259|Pfam:PF16350"
FT   DOMAIN          441..721
FT                   /note="Aminomethyltransferase folate-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01571"
FT   DOMAIN          745..823
FT                   /note="Glycine cleavage T-protein C-terminal barrel"
FT                   /evidence="ECO:0000259|Pfam:PF08669"
SQ   SEQUENCE   833 AA;  93393 MW;  4D8511B6745453E0 CRC64;
     MKTQVKALVV GGGAIGASVA YHLAKAGWDD VVLMERDELT AGSTWHAAGL LPLFNMSYAV
     SHIHQYSVEF YKSLEEETGL NAGFSIVGNL RMARTQERMD EYMLYASTAE TVGVPYEFLT
     PEQIKERWPL VNVEGLKGAI YHPTDGYINP ADVTQAMAKG ARQRGVEIYR KCQVDDYEWT
     GTDWIVRGTI MVEKGGNLVP GDEKFEIRAE HVVTCTGNHA QRTAKMLGIK MPAIPVEHQF
     IVTEPDPALV EYRKTHGEHP VLRDADAKWY VREERGGWIL GPYERGAPAC FEYGVPDSFR
     ADLFPLDLER IEEEYMAMIE RIPSTEEVGL KDDFNGPICY TPDGNPLVGP APGLRNMWLA
     EGFSFGITAA GGTGYYLAQM MVDGEAEIDM ASLDPKRFGQ KWMTTEYAAR KNEECYEHVY
     ILHHPDEERE ACRPLRTGPA YERQKSRGAQ FGVVNGFERP NYFGPLDAAD NFDHDARSFR
     RGGWWQYAVD EAKAIREGVG VVDATAFTKH IVKGPGATAF LDWFTCNKLP KTGRINLTYA
     LTDAGTVRTE YTIVRLKDDE YYLVSAGAWH EYDQDFLIKS VQDKEAEFGR IDVQDVTTQW
     GVFAIAGPKS RDVLNKIIKD ADPATALSNK RFPWLSARQI ELGMCPVNAI RVAYTGELGW
     ELHHPIEMQN YLFDLLEKAG AEFEMKWVGA RAQNWLRQEK SYRAFGNELG RDATPLEADL
     PRFVDLSKEF RGKAAMEAKG VRSKCVTVLI DGPEDADPWG REALYSGDTK IGRLTSGGYS
     VAFGKSIGMA YVKPEFAEAG TKLKVKIRNQ LWDAEITVDS PYDSKNETIR KDG
//