ID A0A2T0ZQC2_9ACTN Unreviewed; 1094 AA.
AC A0A2T0ZQC2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=CLV47_12019 {ECO:0000313|EMBL:PRZ38552.1};
OS Antricoccus suffuscus.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Antricoccaceae; Antricoccus.
OX NCBI_TaxID=1629062 {ECO:0000313|EMBL:PRZ38552.1, ECO:0000313|Proteomes:UP000237752};
RN [1] {ECO:0000313|EMBL:PRZ38552.1, ECO:0000313|Proteomes:UP000237752}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 100065 {ECO:0000313|EMBL:PRZ38552.1,
RC ECO:0000313|Proteomes:UP000237752};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRZ38552.1}.
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DR EMBL; PVUE01000020; PRZ38552.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T0ZQC2; -.
DR OrthoDB; 4812256at2; -.
DR Proteomes; UP000237752; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000237752}.
FT DOMAIN 29..361
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 362..672
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 846..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 50..57
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1094 AA; 118455 MW; 16D0FD79FFB557AF CRC64;
MTATAQGTAA GSRSATYSAV TLAQILGQHS PTDEQIEVIE APMRPGAIVA GAGSGKTETM
AARVVWLVAN GFVEPGKVLG LTFTRKAASE LSSRIRDRLR TLAMSTAGRI EPDEAWLQTE
PTVLTYDAYA RRLVTEHGLR LGVEPSTGLA DAGTLWLLAY QVVSASDAGL EALDVTLRTV
VGWMQQLGDE LLSHVRSLED LDDYCEQNAT HLESLPKKLG KSTGKLTDET LKVARALRSR
QLLIPLLKEF ARAKAEREVM SFGDVMKVGC ELVEKFPDIG DVERGRYDAV LLDEYQDTSH
AQARFLSRLY AGHPITAVGD PCQAIYAFRG ASDDTLASFG HVFGVGEAVT THQLSMSFRN
QESILGLANG VSAPLRERGA EVAQLTAPSG TADGAVSVAF YDDVYAEADA VAARAEQLRT
ADEAAGTSSS VAVLCRARSQ FTPMIKALQA REVPYEVVGL SGLISVPEVA DIVAVLRVLD
QPDASADLLR ILTGPRVRLG SRDLDRLAKL AGRLSGRRAD SAREGATDTP VESDDVDERS
IVEALDSIGD APTDWFSTDG HQRLTRLAGE LRMLRGSLAL PLGDLVTLVE RTINLDVEVA
VRDRRRGAQP GAQLDAFVSV ATGFSSDAGT NSLSAFVRYL HAAEEEDRGL ALAGVETRSD
AVQILTVHAA KGLEWDVVFV PGLVTKKFPA SPDPVEGWLT APKMLPYALR GDVRAQPGID
ITGCVDEVEF KEERARYKDA VADKSALEER RLFYVAATRA RSQLHLSGGT WDEALKPRAP
SEFLIESKEL GPSIGATTPV WADEPAPDAR NPLHADDHAE QWPPQRPLGH FDRLEAAAAH
VRALTDCVHP GPSQGGADEG APPDERADQM LRDTELLLTD RRARRTATDI EIPMPQRLSA
SQMVALHTDA TQFALDIRRP LPRGPQRSAS RGTAFHAWLE QRFGSRALLD LDDLPGSGDE
DVMLDESYDD LIAAFERSEW ADRQPHEVEV PFDISIGGTP VRGRLDAVFA CPPGGRYDYD
VIDWKTGRRP VGEQLAHAEV QLAVYRIAWA RVAGVPVERV SAGFHYVADG TTHRPQSLLR
EDELADLLSA DPAS
//
