ID A0A2T1A065_9ACTN Unreviewed; 737 AA.
AC A0A2T1A065;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=RND superfamily putative drug exporter {ECO:0000313|EMBL:PRZ41999.1};
GN ORFNames=CLV47_107127 {ECO:0000313|EMBL:PRZ41999.1};
OS Antricoccus suffuscus.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Antricoccaceae; Antricoccus.
OX NCBI_TaxID=1629062 {ECO:0000313|EMBL:PRZ41999.1, ECO:0000313|Proteomes:UP000237752};
RN [1] {ECO:0000313|EMBL:PRZ41999.1, ECO:0000313|Proteomes:UP000237752}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 100065 {ECO:0000313|EMBL:PRZ41999.1,
RC ECO:0000313|Proteomes:UP000237752};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRZ41999.1}.
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DR EMBL; PVUE01000007; PRZ41999.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T1A065; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000237752; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000237752};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 521..544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 551..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 584..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 625..651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 663..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 198..327
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 711..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 737 AA; 77320 MW; D457CC96DC76EE96 CRC64;
MHDFLERVGR FSARRHWVVF VAWLIILGAL VGLRSAYGGE FYNNYTVPGS ESSQGLDLLQ
KDFPTQGGYA GQIVFHAKTG SLADQAASID TAMANVAKLP DVIAATNPLT SSPPRVSQDG
TIASGAVSWN VAPASLEKDY LKKLDTAIAP ARAAGLQVEY GAGAGQIGQQ TDDTKSEIIG
LVCALLLLFF MFWSIAAALI PLISAVFSVL AGLSLVGLLA AATNFPTTAP TVATLLGLGV
AIDYGLFLVA RHRENVDHGM DVNDSAGNAT STSGGAVVVA GGTVVVAILG LYVSGVPFIG
AMGLAAAIVV AVTILAALTL TPAFMGVTKG NVRALGKRRR ARSADEAAHE HSAFARWGKM
VSGRPWPWAI AAAIVLCILA IPLFAMRLGQ LDAGTNPTTQ SSRRAYDLVS EGFGPGANGP
LTVVVSLPSQ SQQDNQTLLT NVQSSLAKTS GVASVTPPSV NDAGTTAVLN VVPTTSPQDA
ATSALVDNLR DSVLPSFHAR TYVVGTTAGY VDFTEQTSKR MVWLILAVVL LAFVLLTVAF
RSVVIATKAG LLNLISVGAA YGVVVAIFQW QWGSELIGIH ESLPIPAFVP MLMFAIVFGL
SMDYEVFLMS RVHEAWMQSK DAHRSVAIGI GSTARVITTA AAIMVVVFLS FVLSTDPTVK
MLAVGMAAAV LIDASIIRMI LVPAVMALLG KWAWWMPRWL DRITPHIDIE GSGTETLPQN
PAPSPEKEPP APVTSVG
//
