ID A0A2T2P8I8_CORCC Unreviewed; 5343 AA.
AC A0A2T2P8I8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=BS50DRAFT_670457 {ECO:0000313|EMBL:PSN73965.1};
OS Corynespora cassiicola Philippines.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Corynesporascaceae; Corynespora.
OX NCBI_TaxID=1448308 {ECO:0000313|EMBL:PSN73965.1, ECO:0000313|Proteomes:UP000240883};
RN [1] {ECO:0000313|EMBL:PSN73965.1, ECO:0000313|Proteomes:UP000240883}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Philippines {ECO:0000313|EMBL:PSN73965.1,
RC ECO:0000313|Proteomes:UP000240883};
RX PubMed=29551995; DOI=10.3389/fmicb.2018.00276;
RA Lopez D., Ribeiro S., Label P., Fumanal B., Venisse J.S., Kohler A.,
RA de Oliveira R.R., Labutti K., Lipzen A., Lail K., Bauer D., Ohm R.A.,
RA Barry K.W., Spatafora J., Grigoriev I.V., Martin F.M., Pujade-Renaud V.;
RT "Genome-Wide Analysis of Corynespora cassiicola Leaf Fall Disease Putative
RT Effectors.";
RL Front. Microbiol. 9:276-276(2018).
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Nucleus,
CC nucleolus {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR EMBL; KZ678128; PSN73965.1; -; Genomic_DNA.
DR STRING; 1448308.A0A2T2P8I8; -.
DR Proteomes; UP000240883; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd00009; AAA; 3.
DR CDD; cd17502; MFS_Azr1_MDR_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 9.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR Pfam; PF07690; MFS_1; 1.
DR PIRSF; PIRSF010340; Midasin; 1.
DR SMART; SM00382; AAA; 6.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000240883};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 4841..4867
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4909..4926
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4938..4959
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4965..4990
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4997..5017
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5037..5060
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5067..5089
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5109..5129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5141..5162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5168..5187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5305..5330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4576..4770
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 4844..5343
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 698..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3048..3085
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3939..4326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4362..4481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3325..3352
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 3056..3070
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3972..3986
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3999..4039
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4049..4097
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4098..4114
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4115..4137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4138..4228
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4229..4244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4273..4292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4384..4413
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4422..4436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4437..4453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4462..4477
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5343 AA; 596048 MW; C76AE73AA6F036F7 CRC64;
MASIDITAKK ALEAGSTDDA FFHNEEIFVE VCARWIQSGF QSGAKISAFG RILPLAPHLA
EHVERFLVSA SQSQILGGQS TEVPIPQDEE LLLETLLGTF RLLSYDCRNF AGHVRPLALE
SLVRHSSRTV RYLAVRTLCI YVHAADHATQ EMIKTYVGEG EIEGKWERKT IDYRFLSLWE
EKRWTKLQKR LQEKRQEGLR TVPSGLHHQI SPYSVNVNGI LLPRLDGASS QEKPSDLFPT
PTTDLNQRSI AQRLLDTRPL LLTGLPGSGK TLLIRHFAWQ LNKLSSMVTL HLNEQSDAKL
LVGMYATGAK PGTFSWRPGV LTTAVKEGRW IFIEDLDRAP NEVISTLLPL IERGELLIPS
RGETIRAARG FRIIATMRST LNPKGQEIIP RQNMIGHRFW NSITVHMPKL EEFESIIFAK
YPALQKHLSG ITRVYSRLLA LFSDAKFASE NGTSLRALTP RDLLKWCDRM DVLLSQSTSY
GPAQVDDIFM EAFDCFAGSL RSQEARHKLM ACVAEELHID PQRRDHLLID REVKLELPAK
STSAGIIRIG RARLSKHRSP RKAGYERPFS TNDYTLRLLE KVAVAVDRQE PLLLVGETGT
GKTTCIQYLA DQLGRKLVAF NLSQQSESGD LLGGYKPVNV RSLVIPLKDE FDDLFDTTFS
RKKNARFIEM LGKRVAKGEW KRVCVLWREA LKMVDAARKA HESQASSPDP EGGQPKKKRK
MDSLPADFPK ARWEKFAMDL HDLEAQLASG SEAFAFSFLE GNIVKAVRNG DWVLLDEINL
ASSDTLEALA DLLGGGPDGT PSILLTETGN VERVVAHPNF RVFAAMNPAT DVGKKDLPPG
IRSRFTELYV ESPDTDAKSL RNIVEKYLGG SMVDPAIVRI AADVTDLYME IQKLAKSNLL
VDGADQKAHF SLRTLTRTLS YAREIAPLCS LRRALYEGFH MSFLTFLGKA SEDLVAPLIT
RKLLPSAKAE LKKPLQQPRD ERSYVRQGHY WLRQGVHQVE EQPHYIITPF VQSNMNNLIR
AASTRRYPVL IQGPTSSGKT SMIEYLAKRS GNKFVRINNH EHTDLQEYLG SYISGTDGKL
TFQEGVLVRA LREGHWIVLD ELNLAPTDVL EALNRLLDDN RELLIPETQE VVRPHEDFML
FATQNPAGLY GGRKILSRAF RNRFLELHFD DIPVEELTEI LHRRTMIPES WCKRIVKVYQ
ELSTLRQENR IFEQKSFATL RDLFRWAQRK ADTVQDLANN GYMLLAERVR KEEERLAVKK
VLETVMSRNG PKITVDDEKM FSEDSSPEIK LCKEKMGSGG NVVWTRAMRR LFVLVAHALR
NNEPVLLVGE TGCGKTTVCQ MLADAFEKQL HILNAHQNTE TGDLIGAQRP IRNRAAIEDL
LCRQLIEVLP NAPTDTDLFQ LLALYDQLDS NILDAIPIAH REEIQANRVK ASALFEWADG
SLVHAMKTGQ YFLLDEISLA DDSVLERLNS VLEPSRKMLL AEKGPIDSLV TASEGFQFLA
TMNPGGDYGK KELSPALRNR FTEIWVPALS DLEDILQIVQ SKLKPAAMPY AGSIVSFSQW
FNEKYNTSVS SSISIRDTLA WVTFINNFSA EDPIFGIVHG AAMVFIDTLG ANPAGLLAIS
AASIDDERKA CLHRLSKLLG KDVSPLYFGE ITVTANDNSL QLGSFSIPRF AASSADANFS
LEAPTTRSNC MRVVRALQLS KPILLEGNPG VGKTTLVTAI AKAIGKPLTR LNLSEQTDLM
DLFGSDVPVE GGQAGTFAWR DAPFLKAMKN GDWVLLDEMN LASQSVLEGL NAVLDHRGAV
YISELDQTFQ KHPDFRVFAA QNPHHQGGGR KGLPASFVNR FTVVYADVFR PEDLSLICAR
IFPSIGEDEV QRLIDFVAEL DEKVVNQRTF GALGAPWEFN LRDTLRWLQL LASKEFNGSA
RDFLDAIFVQ RFRSESDRAR ILKLFEDASG ISKPRISLFH NVSPQIFQVG LGLVSRDAAI
TRAGSTFPLR VPQLGPMEAL LISVRQSWPV ILVGPPGSGK TAILDQLSSF VGADLVTFSM
NADIDAMDLV GGYEQIDPSR ELHRFMANLE VYIRRKITSS VNLPQDHFEL LEQLTRSGAP
SLNDILPVFD TVSASDSEAV QLRKDAQNLL DAPTEIDGAR FQWVDGILLR ALEQGKWLVL
DNANLCSSAV LDRLNSLLEP NGYLSINEHS TADGEARIVK PHPNFRIFMT MDSRFGELSR
AMRNRAVEIC LLSDEAPAQD TSRIPTYPLD SQMYRFRHLV AEEASLPQTV DVKSENLSTA
DIGLLQSFPT QASMGLVSVE QELDALDKIS HSSRFLSTVW GARAAAIQSE LNPTQEFLGD
ISSTATLHPL NNELAFNLSS QSETLSLWFA SVYEVFRDLY NMQQAIHALP NSSLERRKEK
QKLISFLKAC WPGLAKCMDA TWKARQSCPA ELGLLKSLRT LFWAFIALAK DSNFERAVFQ
TFLKMLTGDI SSLPDQSIAL VTELKATLSK ELTVFSSDVQ LTSGLGMERI WKYFKPNTPK
DQAQLAAILS LESLADRLDA TMWKSNLKVS EMVQIRERFA SSLELARLHD VDAGELIVAL
DVAVSELEGN IDEDATVITP YFEEEFEGLC QLLEVAPATP NKDNITVMRA KTSLFARRPT
KLSDNAPANT PTGLTSALTR YVGRDQHPAR EMALRGRFHI ALLEKIRNAD EVQLLQLDRF
ESELQALAQE LTLDSDHIEW DQNAALRPIL RRVLDHLVES HQDILSGSAT SIKVSDQYRK
AIEQPIARCE HSADPAHLAL AQAWIHLGLT GLSLYIPNYP HDPALRPMIE RKLFNEEKSA
LMEKLRALKQ FQLEFTGQET SFRIRQIEEA IQQMGAEPPV PAIVRPDTSE LDTLQGEFTN
LLSVIQPLLQ ETMSLQEATH DNTLRQNLAH ITKRLVEGYR SYDDITEPAV GFLTCLSIGL
ALGAQEEQDE SNIKRSLQYI VQQTPFFGHK SANDSKSLLR YCEQEFDKKH VVDIRWHTLH
TLSIIRSVDD ACYFTSQLRQ MIHDIFTSFY SDWKSQLLKD QESEAKNTSL YTYRGEDEDG
DEEDPSLFPD YEQEQAEPTT PSTSREHAIR VANMHTELFL DARDPSDSLK RLLEWCRTEM
TRVSDSDAHG TSPTDALPAI YLAFEQKVDA LSSSGTGKGY NFYFDANLPE AKRLIQLIHQ
IQIRYRQIQK VWPEHATLAD VLRTCDEALA FRHVDPVAKF ITKAEKLHGY IYEWQRVASR
QFNTSNLYDD LTKLLVGWRQ LELTTWARLF DIETDKCRDD AKSWFFIAYE TIIAASESIE
DQASMETHAQ RLLKTMEEFF SSTTLGQYEQ RIKLLQQLRE HLAARMQDVE SLKPVHLALS
NFITYFSRLE KPVHEALSKG RQNLEKEVNN VIKLASWKDT NIEALKQSAK TSHRKLTKLV
RKFRALLNQR VATIYGTGFP EEAALLKAVE LPGTETEVDP TALEICAAHV PRWIECPTRF
KNLKVTVSMM RNFSTPSPES LDGAEYIDEF ITDLEASITQ LQKATPTTLT EENKEAVQHL
KTRKRKLYAD TMKELRQMGI KFNLSSDVLT KQYELSIVLA SLPTVSEAGK GAEYFLHKAL
NIMGQVRDVA KEHSGDLTPN DVARSIGYIE GLLHSTLRQR SVLSKATQSL GSMQQPISLI
GNLCDSLSRP LVRVSDNQIQ AANNLKPNLS WLVAALRTGA DIVAAQAKLG KTNEVDAVIR
NMREWSEKFQ DALEATARLP ILPLNVWSAA HRELDEKSKQ LINDFRPALA TLFEQYPVSR
VVLSHIQPFV FEYSQPNAQI FDEKKRISVE ARSEEILKAL DLILGSMQDV KTSLQDIPSS
NEDEKWLVKE EKALADAVHS LHAPQITAAL QTILESMQYL YEDENLRTIA AMFAAVQPIL
AQYATTHKYL VDRFDALHQS TAKLLHRLSK TFIQIGTQGF CQPPEKSNDP QAGKDDKLES
GTGLGEGEGA EDISKDIEED EDLEDLAQEK NGERENSIEN EDDAVDMGEQ EMEGEMQDAP
EKEDGEEGEE GEEDAQSEVG SVDDLGPSAV DEKMWDEGGK EEDAKEKEGQ KDVGTENQDE
QVATEKKEDG KEGEKDDKQP EEEEEEMEME GEDQEENVGM GKEEPMDPHA KEEETLDLPD
ELNIDGDDND KEDDLGDMDM DDDLPPEETD ADPGAEPDKV DEEIGPEQDG EEEEETTGHI
KDDEMEEKED EGEEGDEPVD DDPVPMPDEN IPDEARDTKN DDPSDPNADV GAGADANEEA
HKNQQEQASA SAANREDGKE GDSSEQKQET NAEDGELGQT AQPDAGGKGE QPEDSPETQS
FKKLGDVLEK WYNQQRKISE AKERDETQIQ QIEKEVDMAD ADFEHLRDEE QEADTQALGT
ATEEQAKHLD EDMGMAVDEE EKMPARPEDN QDPAQDADQD VDMNDTEPKQ EQEQEQPQSK
TDGQPQAFVG EQKPFTQEDQ DMEDAVPLEE DESDTSSVNE VETQLELTHL DANALTSPDE
ARALWLNHEA STHSLSQQLT EHLRLILAPT LATKLRGDFR TGKRLNLKRI IPYIASGYKR
DKIWLRRSQP SKRSYQVMIA LDDSKSMAES GASNLALKTL TLVTRSLSML EVGEVSVVGF
GDGVNVAHEF EKPFTSESGV RVFEQFGFAS SKTNVRGLVD KSLDLFADAR RKGSSSAGED
LWQLMLIVSD GICDSHAEIQ RLVRRAQEER VMIVFVIIDS SATPGPAQAG QQPDGTLAEK
PKEKTSILDL QSVEISAQGK VVRWKYMERF PFSPQPNTST PIKMTTYISN SGGSSTEVIE
AIELTPLPPR SIKDELEPQA HDSPPDPNAG VPITYPKNIR LALITIGLIL SIFLAALDST
ILATAIPSIT SQFGSISNIA WYGSSYVITN TAFQSAWGKA YNYFSIKRTF LAAIAVFELG
NVISAVSSRS EILILGRCVA GMGGGGVMTG SFLGIALSVR DEWRAAYMGV MGVTFGVASV
VGPLLGGALV DGAGWRWCFW ISLPIGFAAA GIMFFAFRDP ISPRQASLKE KIMQTDINGA
ILITGALSFF VLAMHWAGIY PWRSPRVIGS FVGFGVLFIA FVVNEWLMGS KAMVQAHLMK
SSIVLTNSIY AFFLAGAYFP LLYTLPIHFQ SVDNSSASQS GVRLIPLVLG ISVFTMIANG
LITFWRHYRP FLLVGAICST AGLWLIYSLD AHTPIKTWVG YELLTAIGIG LALQIPMISN
QAHVPASEIP SATSLALFME NIGTSLFVAS GESAFTQGLV QSLKRNVPSV EPHKVLDAGA
TQIRETFEGS TLEGVLGGYL DGCRVSYAVC LACGVAACIV AMGGAGPAGF KEMKRRMAKS
HET
//
