ID A0A2T3A7Q6_9PEZI Unreviewed; 506 AA.
AC A0A2T3A7Q6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN ORFNames=BD289DRAFT_368568 {ECO:0000313|EMBL:PSR84425.1};
OS Coniella lustricola.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Diaporthales; Schizoparmaceae; Coniella.
OX NCBI_TaxID=2025994 {ECO:0000313|EMBL:PSR84425.1, ECO:0000313|Proteomes:UP000241462};
RN [1] {ECO:0000313|EMBL:PSR84425.1, ECO:0000313|Proteomes:UP000241462}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B22-T-1 {ECO:0000313|EMBL:PSR84425.1,
RC ECO:0000313|Proteomes:UP000241462};
RA Raudabaugh D.B., Iturriaga T., Carver A., Mondo S., Pangilinan J.,
RA Lipzen A., He G., Amirebrahimi M., Grigoriev I.V., Miller A.N.;
RT "Coniella lustricola, a new species from submerged detritus.";
RL Mycol. Prog. 17:191-203(2018).
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. Dihydroflavonol-4-reductase subfamily.
CC {ECO:0000256|ARBA:ARBA00023445}.
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DR EMBL; KZ678443; PSR84425.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T3A7Q6; -.
DR STRING; 2025994.A0A2T3A7Q6; -.
DR InParanoid; A0A2T3A7Q6; -.
DR Proteomes; UP000241462; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10366:SF447; HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06450)-RELATED; 1.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000241462};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 87..370
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 506 AA; 55793 MW; A4C9B665861BD9CC CRC64;
MARILPSYTE PYNIAVAVFH LLSLFLIIYL VNLNRLLNST PPEVQKLVPR RWTQAEIKNT
YNRLCKDPIT TASYKAELPP RLQRRYVVTG GSGLLGGYIV LQLLERGQPP NTIRIVDFQT
PHRSDLLCGP GKLVPFYKAD ISSAASTEAA FDAPWDKSVA DLPLTVFHTA AVIIPSARSP
LVNAFCEAVN VHGTAHVLAS ARNAGADVFI STSSASIAVQ PVEFWAAPWK WRHHPQNSAQ
ILDESDFFRP LQAHDEFWGN YPASKAKAER MVCNANAKEL RTGCIRPANG VYGHPSDNLL
GAPLSMQIYP QWVRNNVQSF VHGVNCALAH LQLEAVLAKP DSYTAPQAGR PFCITDPNPP
IYYGDLHNVL SMLARTPFRI VTIPPVLMLL LSYAVEFYNL LPLRVPFLAG SLPRLPGGLV
YLEPGLFTIC THLVGNMNEA CKPVEQGGLG YRGVLTTLEG MCQELVDWNR EQEEHAKEGL
KAHYRSSVFL AEEIRKGGGT LIAVGT
//
