ID A0A2T3ANQ2_9PEZI Unreviewed; 4346 AA.
AC A0A2T3ANQ2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=BD289DRAFT_358122 {ECO:0000313|EMBL:PSS05288.1};
OS Coniella lustricola.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Diaporthales; Schizoparmaceae; Coniella.
OX NCBI_TaxID=2025994 {ECO:0000313|EMBL:PSS05288.1, ECO:0000313|Proteomes:UP000241462};
RN [1] {ECO:0000313|EMBL:PSS05288.1, ECO:0000313|Proteomes:UP000241462}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B22-T-1 {ECO:0000313|EMBL:PSS05288.1,
RC ECO:0000313|Proteomes:UP000241462};
RA Raudabaugh D.B., Iturriaga T., Carver A., Mondo S., Pangilinan J.,
RA Lipzen A., He G., Amirebrahimi M., Grigoriev I.V., Miller A.N.;
RT "Coniella lustricola, a new species from submerged detritus.";
RL Mycol. Prog. 17:191-203(2018).
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; KZ678372; PSS05288.1; -; Genomic_DNA.
DR STRING; 2025994.A0A2T3ANQ2; -.
DR InParanoid; A0A2T3ANQ2; -.
DR Proteomes; UP000241462; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000241462}.
FT DOMAIN 1923..2061
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2580..2734
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2922..3088
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1164..1191
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1626..1653
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3170..3239
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3410..3444
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4346 AA; 492939 MW; 12C3F2B384B67DF7 CRC64;
METAAPPQLS AVSPLNGDGN DVNGTAAVAM DPGRVVDHLA QLLEATLGAT GDELAASGSL
LSEARLSDTL HRCSRFINDG QSLYIQKDLP AAPQLENGDG EHRPPVHTYT IASDLSSTAT
TVAFLVLLKR PQPLDPAVPL SSQLHFLNLP GPAHLAATAS EQGPSASPFE YLQLFLHNGL
APYFDASTKS QQMIGGSRGR ADIDAKTGIP VTKKRWTELE LSLSHLQQNV EIPEVLLPFN
TIVQTALDDA SARHTKPTLD LIPATLLSDS QFLNKLQANV NNWIKSIQVI TKMNRDPATG
TANQEINFWL SMEAALGGIE AQLSSEGVHL TLAILKHAKR FQATVSFGAD TGLKEAMDTV
QKYNQLMRDF PLDELLSATS LPKVRDAIEQ IFTHLNKKLR ICPYPIRRAL PLVEAISADL
DEVLHRLLPG TELVDLDYQE FRNVMRMTER IFTAWDEQRK AFTDVARDVT RRRNEKFIPI
KINPRHAELQ ARLKYVSNFR DNHEQLQKTI VDVLGPKAVV EVTDGATAGG IIVEEMGDVD
AVEEVKQAWE ALRNVDLLDV SSEGTQKWVK AEDTYNERTS RVENSIIARL RDSLATAKNA
NDMFRIFSKF NALFVRPKIR GAIAEYQTQL IDNVKQAINS LHERFKQQYG HSEAHAMAQL
HDLPPVSGAI IWARQIERQL DGYMKKVEDV LGADWAIHTE GEKLKNESDL FRKKLDTRPI
YEAWLHDVQR KQITISGLLF TVSRIRSAGN ILELRVNFDA QVIALFKEVR NLLWLNYAVP
HAINTVSKEA KRVYPFAVSL MESVRTFAQT DRQIADMPDV SVLLSGYRND VQAAILKGVP
LRWESFNNMY ELHFRADPSK SESKHVAFVK ELASKVSILQ AKTMMLATIN LTIQKSLTEL
STCPYEATAF ESRLRVIQEA VDQLNLEQYV NLGYWVDGMN NQIKATLLVR LQHAIQLWID
AFEDEHAESE NTRRRTVTDI TLETKANKPA MKKLIHEITM RNQVIHLDPP LEYARASWFI
QFQEWLGVIC NLHKIKATRY QMSLSTAVYE EPKFNDLPAE CTDMLARVHG SVEKKLSEVG
GYVDEWLRFQ SLWDLQSDQV YDLLGDQLSR WLQLLQEIRK TRQTFDTSDV SRSFGHITID
YDQVQTKVNA KYDQWQHDIL LKFASRLGNR MRDVHAELEK ARRDLEGQSL EASSTAQAVQ
FITIVQSCKK QVKFWAPEVE IFRQGESTLV RQRYQFPNDW LHAEQVDGMW DALNELLARK
SKVVQDQTDA LRAKITAEDK VVADKITEVA QQWDEEKPVS GTIPPDEANV TLSSFESRIT
QLQAEFAMVA KAKEALDLPA SGDSSLAVIL EEVQDFKSVW ASLALIWKSL NELREMLWTS
VQPRKIRSSI DNLIKMTKDM PSRMRQYAAF EHIQNILRQY LKVNSLLGDL KSEAVRDRHW
TKIWKQIKPG KRYSPVSMTL GDVWDLNLVA TEVIIKDIIT QAQGEMALEE FLKQVKEDWT
NYQLDLVNYQ NKCRLIRGWD DLFAKCSENL NSLQAMRHSP YYKEFEEEAS TWEDRLNRVH
VLFDVWIDVQ RQWVYLEGVF TGNADIKHLL PIESSRFQNI NSEFSAVMKK VYKQPTVLDV
LNIPNVQKSL ERLAELLNKI QKALGEYLEK ERVSFPRFYF VGDEDLLEMI GNSNDTLRIA
KHFKKMFAGL SGLLMDEEGV ISGFTSKEDE VVRLKKQISV IQTPKINDWL ALLESGMRST
LAELLAEAVE QYTPIFSSEN IEPAALNDFM QAYPSQIVVL ATQAVWTTAV DQALANGGTD
LQSLFEREVQ VLRLLAETVL GDLEVLLRKK CEQLITECVH QRDTIEKLIN LNATTPTHYM
WLLQMRYVYN PQGEYTERLH IKMANAKLNY GYEYLGVPDR LVRTPLTDRC FLTLTQGLCQ
RLGGSPYGPA GTGKTESVKA LGVELGRFTL VFCCDDTFDF QAMGRIFLGI CQVGAWGCFD
EFNRLEERIL SAVSQQIQNI QLGLKQGVED ENAQIELVNR QLHVNENTGI FITMNPGYAG
RSNLPDNLKK LFRSVAMSKP DKELIAEVML YSQGFNQAKQ LSKHTVPFFD QCAAKLSKQA
HYDFGLRALK SVLVSSGGLK RARLVENNGK LGSEEVVEPE IIVQSIRETI APKLIKSDVD
IMMDIEEACF PNVKYVPANL HKLEDAIRRL AGERQLVVTD LWMTKILQLY QIQKIHHGVM
MVGNSGTGKS AAWRLLLDAL QLVEGVEGVS HVIDSKVMSK EALYGNLDST TREWTDGLFT
SILRKIVDNL RGEDSKRHWI VFDGDVDPEW VENLNSVLDD NKLLTLPNGE RLNLPSNVRI
MFEVENLKYA TLATVSRCGM VWFSEDTVSP SMMVENYLNT LRTVAFEDLD EDAVATGQSS
AKALAVQTQA ADLLHAHLDT NGFILAALKE AEGYNHIMDF TVARVLNTLF SLLNKAVRDI
IEYNNQHVDF PLDPEQIEGF ISKKLLLALV WALTGDCPLT DRKTFGDQVC GLADFGSPPL
DGSSALIDFD VSLPQGEWTP WQNQVPTIEV NTHSITQTDV VIPTLDTVRH EDVLYSWLAE
HKPLLLCGPP GSGKTMTLFS ALRKLPNMEV VGLNFSSATT PDLLIKTFEQ YCEYKKTLNG
VMLSPTQIGR WLVIFCDEIN LPAPDKYGTQ RAISFLRQLV EHNGFWRTSD KAWVTLDRIQ
FVGACNPPTD AGRTPMGDRF LRHAPLIMVD YPGEQSLMQI YGTFNTAILK IIPSLRGYAE
PLTQAMVRFY LESQQRFTPK IQPHYVYSPR ELTRWVRGVY EAIRPLEALS VEGLIRIWAH
EALRLFQDRL VAEDERKWTD DAVHRIALDF FPTIDEQQAL GGPILFSNWL SKNYIPVDRE
QLRDFVKARL RTFCEEEVDV PLILFNDVLE HVLRIDRVFR QPQGHLILIG VSGSGKTTLS
RFVAWMNGLK VYQIKVHGKY SAEDFDEDLR EVLRRCGCKG EKMCFIMDES NVLDSGFLER
MNTLLANAEV PGLFEGDEFA ALMTACKEGA QRQGLLLDSQ EELYKWFTSQ IVKNLHVVFT
MNPPEDGLSS KAATSPALFN RCVLNWFGDW SDQALFQVGH ELTQSVDLDR PNFQAPDTIP
VAYRALSLPP SHRETVVNSM VYMHYSLARF NDKLRKQQGK VTFLTPRHFL DFITQYVKLY
NEKREDLEEQ QRHLNVGLEK LRDTVDKVRD LRESLAEKKA QLEQKDIEAN EKLQRMVADQ
REAEQRKTTS LEVQAALEKQ EAEVASRKKV VLEDLAKAEP AVESAKASVS NIKRQHLTEV
RSMNTPPSGV RLALDSVCTL IGHKVSDWKA IQAVVRRDDF IASIINFDNE RQMTRPLRIK
MRNEFLSNPE FTFERVNRAS KACGPLVQWV EAQVNFAEIL DRVGPLRAEV DQLEEQALQT
KAEAKAIENN IIHLEQSIAT YKTEYAALIS ETQAIKSEMQ RVQFKVDRSV KLLDSLSSER
VRWEEGSKSF ETQISTLVGD VLIAAAFLAY SGLYDQTFRK GMLEDWLHQL HLSGVQYKPH
NPFTEYMSTA DERLKWQENS LPVDDLCTEN AIILKRFNRY PLIIDPSGRV NEFLQKECKD
RRLTVTSFLD DSFTKQLESS LRFGNPILIQ DAEHLDPILN HVLNKEYQKT GGRVLIQLGK
QQIDFSPSFK IYLSTRDPSA TFAPDICSRT TFVNFTVTQS SLQTQSLNDA LKSERPDVDE
RRSNLIKLQG EFKVHLRQLE KRLLQALNES RGNILDDDNV IETLETLKTE AAEISAKMSN
TEGVMAEVDQ ITLEYDVIAK SCSAVFTVLE QLHYLNHFYQ FSLQYFLDIF HRVLHNNSNL
EKETDHRVRR DIIVKDLFIN TFKRTALGVL QKDRITLAML LAQASPYKMD KDLIDVILDE
KIPGKDISTE KEDVDEAFAS ARKVPALKEK LDAVSQDDWD RFLSEELAEN CVPKIWSDDT
DSTDQALFSL LLIKLFRLDR FVPAAERFVG LVFGNDFFDV VEDLKATVSE VPATRPVALV
STPGFDASYK VDSLVERSRV RCTNIAMGSE EGLASADKAI SHAAQVGSWV LIKNVHLAPT
WLQSLEKRMD SLNPNPDFRL FLSMESSPKI PVNLLRASRV LMYEQPAGVR ANMKDSMSSL
SARPNKSPVE RQRLYLLLSF LHAVVQERLR YAPNLGWKGF WEFNDSDYEC SAFVIDTWVE
TVAQNRTNIA PQNIPWDMIR YLVTETYGGK IDDEGDFKLL NQLVHSFLTP AAFDIGHKLV
EGGGVGGGIN SNEGSLEVPS GTSMQDFMNW VHKLPEREPP TYLGLPANAE KLLLVGLGKS
MIQNLRKVTD LLDESEQVMA EAAQAA
//
