ID A0A2T3HPP9_9SPHI Unreviewed; 801 AA.
AC A0A2T3HPP9;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:PST84361.1};
GN ORFNames=C7T94_06515 {ECO:0000313|EMBL:PST84361.1};
OS Pedobacter yulinensis.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Pedobacter.
OX NCBI_TaxID=2126353 {ECO:0000313|EMBL:PST84361.1, ECO:0000313|Proteomes:UP000240912};
RN [1] {ECO:0000313|EMBL:PST84361.1, ECO:0000313|Proteomes:UP000240912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YL28-9 {ECO:0000313|EMBL:PST84361.1,
RC ECO:0000313|Proteomes:UP000240912};
RA Keele B.F.;
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PST84361.1}.
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DR EMBL; PYLS01000004; PST84361.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T3HPP9; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000240912; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000240912}.
FT DOMAIN 7..205
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 208..307
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 390..439
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 801 AA; 88502 MW; 3843F009AAC1A2FB CRC64;
MKRTIKKVAV LGSGIMGSRI ACHFANIGAE VLLLDIAPKE LLEEEKAKGL TTADAKVRNR
IVDAALQTAV KTNPSPVYSK KVLSRITTGN FDDDMVRIRD CDWVVEVVVE NLDIKKKVFD
QVEQHRRPGT LITSNTSGIP IHLMAEGRSD DFKANFCGTH FFNPPRYLRL LEIIPTAFTD
AGVVAFLMEY GDKFLGKTTV RCKDTPAFIA NRVGVYSIMA LLHLVEKLDL TVEEVDKFTG
PALGRPKSAT FRTSDVVGLD TMIKVAKGLY DNCPDDKARD LFKLPDFVQK MEENNWLGDK
TGQGFYKKIK GADGKSEILA LDLKTLEYKP QQKVKSATLE MTKPVENLRE RMRIFAAGKD
KAAELFRHSS FGLFAYVSDR IPEISDELYR IDDAMRAGFG WELGPFELWD AIGLSASVEG
MQTYGHQPAA WVRQMLEQGH DTFYKVEDGR KKYYDVATAS YQPVPGTEAF IVLDNLRQNK
TVWKNSGVSV IDIGDGIVNV EFHTKMNTIG GDVIQGINKA IDLAEKDFQG VVIGNDGANF
SAGANVGMIF MMAVEQEWDE LNMAIRAFQN TSMRLRYSSI PVVVAAHNLT LGGGCEFSLH
ADHVQLSAET YMGLVEFGVG VIPGGGGTKE FALRASDELK DDQIAQNTLK ERFLTIGMAK
VSTSGEEAFE LGYLQKGKYA ITMNRSRLLA DAKAKALELA DAGYTKPVQR NDIRVLGKQG
LGIVYAGANS MYAGNYISAH DKKISEKLGY VLCGGDLSSP TEVTEQYLLD LEREAFLSLA
GERKSLERIQ SIITKGKPLR N
//
