ID A0A2T3MVF7_9GAMM Unreviewed; 722 AA.
AC A0A2T3MVF7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Tyrosine-protein kinase {ECO:0000313|EMBL:PSW03946.1};
DE EC=2.7.10.2 {ECO:0000313|EMBL:PSW03946.1};
GN ORFNames=C9I89_15790 {ECO:0000313|EMBL:PSW03946.1};
OS Photobacterium lipolyticum.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Photobacterium.
OX NCBI_TaxID=266810 {ECO:0000313|EMBL:PSW03946.1, ECO:0000313|Proteomes:UP000240904};
RN [1] {ECO:0000313|EMBL:PSW03946.1, ECO:0000313|Proteomes:UP000240904}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16190 {ECO:0000313|EMBL:PSW03946.1,
RC ECO:0000313|Proteomes:UP000240904};
RA Butler K.;
RT "Whole genome sequencing of Histamine producing bacteria.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PSW03946.1}.
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DR EMBL; PYMC01000012; PSW03946.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T3MVF7; -.
DR OrthoDB; 9775724at2; -.
DR Proteomes; UP000240904; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:PSW03946.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000240904};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:PSW03946.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 32..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..107
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 369..450
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 530..651
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
SQ SEQUENCE 722 AA; 79927 MW; 1FE6E1C735914C65 CRC64;
MNPNQLNTTV AKSNADEIDL GKLFGILIDN RWNIILITFI FAVVGVAYAL LATPIYKADA
LIQVEQKSSG MPALGDMGEM FGSESSATTE IEIIKSRMVI GKTVDKLNLT TVVTPNYLPV
VGKGLARLQG EQADIDIGRF EVPDYVSQPV YTLTVTDSDT GNYVLTDKDE REVLSGKAGE
LALQGDYRLF VSLLKAEDGA SFTISKRSRL DAIQELQQNL AVSERGKQTG ILQLSLTGEN
RADIERILND ISQYYFLQNV ERNSAEAENS LAFLRTHLPD IKTELTASED TLNRYRQEND
SIDLGLEAKS TLEVMVSLEA QLNELTFKES EISQRFTKEH PAYISLLDKR KTLLSERERL
NRQVQKLPKT QREVLRMTRD VEVNQQIYVQ LLNKVQELNI VKASTVGNVR ILDSAKSYTR
AVKPKKPLIV VLATLLGGML AVAIALLRAA FHRGVESPDE IEAIGLPVYA SVPMSDWQIE
LEKKQKSKKQ LSVQETLLAV SNPADLSIEA LRSLRTSLHF AMMEAKNNIV MISGPSPGIG
KSFISANMAA VIAKAGQRVL IIDADMRKGQ MERQMAVTHT PGLSAYLSGQ ENIETLIKEP
GVENLHYIGR GAVPPNPSEL LMHPRFKALM EWASENYELV IVDTPPILAV TDPAIVGAHA
GTTLLVGRFG QNAVKEIEVT KQRFEQNGIE VKGFILNAVV RKASSYYGGN YGYYNYSYES
NK
//
