ID   A0A2T3W4W6_9DEIO        Unreviewed;      1324 AA.
AC   A0A2T3W4W6;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=C8263_15295 {ECO:0000313|EMBL:PTA66931.1};
OS   Deinococcus arcticus.
OC   Bacteria; Deinococcota; Deinococci; Deinococcales; Deinococcaceae;
OC   Deinococcus.
OX   NCBI_TaxID=2136176 {ECO:0000313|EMBL:PTA66931.1, ECO:0000313|Proteomes:UP000240317};
RN   [1] {ECO:0000313|EMBL:PTA66931.1, ECO:0000313|Proteomes:UP000240317}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OD32 {ECO:0000313|EMBL:PTA66931.1,
RC   ECO:0000313|Proteomes:UP000240317};
RA   Wang X.-P., Du Z.-J.;
RT   "Draft genome of Deinococcus sp. OD32.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PTA66931.1}.
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DR   EMBL; PYSV01000017; PTA66931.1; -; Genomic_DNA.
DR   OrthoDB; 9815272at2; -.
DR   Proteomes; UP000240317; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR   InterPro; IPR046816; MmeI_Mtase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   Pfam; PF20473; MmeI_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          471..549
FT                   /note="MmeI-like DNA-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF20473"
SQ   SEQUENCE   1324 AA;  147896 MW;  572B8552372B1396 CRC64;
     MSATQLQHVR VHGLGLTDDF LLQLSDRAQT AKVEGATPVS YDLPPRTSLE EAIRDAWADA
     RKAWLKYTAH GTDTWAGWIR PLLKALDYSF PGGGATGGKY AVNHLSETGD VPLHFTKQPD
     LDRVTDETGL RVSPHGLMQG YLNAMPEHLW GLVTNGETLR LLRDNAQVTR PAYVEFQIGE
     MLRTEDARAF RVLWLLLHRT RLRGGKAGVL EKWNEASKAL GQRANDTLRD GVQLAIEHLG
     TGFLQHNPSL LERTRSGEVT AQDLYRAALT TVYQMVFLFV TEDRDLLFAR DEQGEYVPDA
     QTRARAAHYL TQSLRQKAGA LHGNPTHIDA YVGWERLLDH LRTGFPSLGL PALGSLLFQT
     NLLSGLKLGN EAFYNAVRAL SEISVNGSLR PVNYAGLDSE ELGSIYESLL ELVPRIEPGP
     RFSLTVLPGN ERKSTGSYYT PSSLIGLLLD SALDPVIDDA VRDKLPQDAM AALKGLKVID
     PACGSGHFLI AAARRIGVRL AELEEETSQP SPRALRRATR TVIAHCIYGA DINPMAIELA
     KVALWLESQD AGKPLAFLDH RLRVGNSLLG ITEEGMQVEE VLKDTSRTRT TDKETVVRLL
     GLTDEAFSVL EGDEKKTVAD LKKRNKQERK ALAPAAGNQP TLLGASSLGI KLGALNRIEP
     NTLQDVQAQA STFQAIEVDT ERLRRKALAD AWCAAFVLPK VPGAPAMTTA DLYRLQAGEA
     LPALRQAVTE TARQYRFLHP HIEFPDVFGD QGKGGFDCVL GNPPWEQVQL DPQEFFAATH
     PDVANAANMA AREQLIAELE DTDPTAFKTY LDAKRELEGV QHFLHSSGRY PTTSFGRLNT
     APLFSELATQ WVNGKGAMGI IVPTGIATDS FNQYFFNALV DSRRLISLFD FENREALFPG
     VHRSFKFCTL TVGGEQRTTD AAQFSFFALQ PSDVQDSEKR FELSPIDIAL LNPNTRTTPV
     FRSRKDAELT KAIYQRIPIL FREATTRVEN GEEVIVPEEN PWGIKFMLMF MMNTGSRIFR
     TAKQLEAEGW ALDGNRYRQG ERRMLPLYEA KLMHQFDHRY ATYTDSGDTR DLTSAEKADP
     TCLPLPRYWV AEGEVEDRLI QRDKNGRVVW AWPRDWLMGW RDIARSTDER TFIGAIYPRR
     AAGDTFLQMF PSCSVAQIPG LLGTLNSFAH DFAVRQKVGG THLKYNVTRQ FPVLPPSAFT
     PLLLAFITPR VLELTYTAHD LRGFARDLGY AGGPFTWEDE RRFWLRAELD ALYFILYGIK
     QDEVEYIMET FPIVKRKDVA AHRSYRTKQA ILSVFDELSA LGLDYLHKYR SRVPGGQVAG
     GWVP
//