ID A0A2T3YSM8_9HYPO Unreviewed; 1023 AA.
AC A0A2T3YSM8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Sterol regulatory element-binding protein cleavage-activating protein {ECO:0000256|ARBA:ARBA00019541};
GN ORFNames=M441DRAFT_62805 {ECO:0000313|EMBL:PTB35524.1};
OS Trichoderma asperellum CBS 433.97.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=1042311 {ECO:0000313|EMBL:PTB35524.1, ECO:0000313|Proteomes:UP000240493};
RN [1] {ECO:0000313|EMBL:PTB35524.1, ECO:0000313|Proteomes:UP000240493}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 433.97 {ECO:0000313|EMBL:PTB35524.1,
RC ECO:0000313|Proteomes:UP000240493};
RG DOE Joint Genome Institute;
RA Aerts A., Atanasova L., Chenthamara K., Zhang J., Grujic M., Henrissat B.,
RA Kuo A., Salamov A., Lipzen A., Labutti K., Barry K., Miao Y., Rahimi M.J.,
RA Shen Q., Grigoriev I.V., Kubicek C.P., Druzhinina I.S.;
RT "Multiple horizontal gene transfer events from other fungi enriched the
RT ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead
RT plant biomass.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004557}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004557}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the WD repeat SCAP family.
CC {ECO:0000256|ARBA:ARBA00007410}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KZ679275; PTB35524.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T3YSM8; -.
DR STRING; 1042311.A0A2T3YSM8; -.
DR OrthoDB; 1422944at2759; -.
DR Proteomes; UP000240493; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0032933; P:SREBP signaling pathway; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR030225; SCAP.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46378; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR46378:SF1; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000240493};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT TRANSMEM 193..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 192..350
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 36..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1023 AA; 113022 MW; 82AB21C6EEB5F8AB CRC64;
MRSIWIHSSY MQALSPDVLL SALELQDELL GTTQDFNPGR YSGLPPPGDP NAPLSPAQRD
ALHVVNGLTD QSWAFQSPLL YWNCSRERIL ADEDILATVN DRKNQSTPAN ITLRHSIVFS
GKRFEDRRLL AADALVITLL YRNASPVGRH WEDVAPSLPA KVGDKWDIYP ANGQVSGSQL
YEFKFRPITA QDSIIFAVAY AVALLYFLIN LTKLRAIKSK FGLIVTVIAQ ILLSIVSSLT
VCAFLNLDLS RIPRAAYPLI VLIMSLDHIL RLMNALIRTP SEDSTSNRIG YAFGEIAPAA
LATSIQNCAI LIALSRVVSP GVSEFCIFAA VAIVLDTFYL STFFLSVLSV DVRRMELGDA
LAKESMRRNR NANYSRNSSW VKRIVQGKIA LSTRVAGTLV VLGFVFIAQS RFFSDRDISR
RLSQLYGGKN LEPSLPSPLK TSLLNEIHQA RSPTSWLLLQ DHDAAHEIIR IIKPSAYSYI
ARVYEPLVFV KKGSNRAPRM KESILSPAVL DFINHQLTPL VFIDVLVVFL LRRLTAYLLP
DDKAKREGLS DSSEEPSLGV KTLSGGHCLD IAMLAYSSGG YAVSVGLDRK ICLWSLNNED
RCFTISDPER DIGIKFPVLA IAIDEDSEWL AILSSDAVTF WNIATNVQGP IIAAETYNQK
PTAFFLDPNV SSNIPRPVIV WKNGTVVDIE PASGESREFM LCSGLTCARQ LISIAGEHQS
PTVFLIATSR NGDIHVVERI GMSWGEQKVF TGKLVVDEIH QVVPLSPLAY FLASSKSDVH
LINLNDGSTA WSFSIENLRP RSLDCAFSCH RASNAMSIGL KSFTLSYQAL DSGDGILHTF
TPHEDDDAIF LQNYGIDRAI SGWCGWSEAV QTTKRIDNPG VWRLLYDGSA IGLRRRPRTE
SRNRQQKAIS SVRNRLPNAK SQEVGAFNCW ELWRAAPGDR QDIDEITPLF PSDEDPGQMI
VCEPGPGVKF GESSVAFAFG NVIKVATLSG YKPSGINEVS HESLMNMPTR RRKGGTMARP
TGT
//
