ID A0A2T3Z9D7_9HYPO Unreviewed; 1168 AA.
AC A0A2T3Z9D7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE AltName: Full=Mitochondrial DNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00031966};
GN ORFNames=M441DRAFT_68449 {ECO:0000313|EMBL:PTB41424.1};
OS Trichoderma asperellum CBS 433.97.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=1042311 {ECO:0000313|EMBL:PTB41424.1, ECO:0000313|Proteomes:UP000240493};
RN [1] {ECO:0000313|EMBL:PTB41424.1, ECO:0000313|Proteomes:UP000240493}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 433.97 {ECO:0000313|EMBL:PTB41424.1,
RC ECO:0000313|Proteomes:UP000240493};
RG DOE Joint Genome Institute;
RA Aerts A., Atanasova L., Chenthamara K., Zhang J., Grujic M., Henrissat B.,
RA Kuo A., Salamov A., Lipzen A., Labutti K., Barry K., Miao Y., Rahimi M.J.,
RA Shen Q., Grigoriev I.V., Kubicek C.P., Druzhinina I.S.;
RT "Multiple horizontal gene transfer events from other fungi enriched the
RT ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead
RT plant biomass.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
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DR EMBL; KZ679261; PTB41424.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T3Z9D7; -.
DR STRING; 1042311.A0A2T3Z9D7; -.
DR OrthoDB; 5403095at2759; -.
DR Proteomes; UP000240493; Unassembled WGS sequence.
DR GO; GO:0005760; C:gamma DNA polymerase complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006264; P:mitochondrial DNA replication; IEA:InterPro.
DR CDD; cd08641; DNA_pol_gammaA; 1.
DR Gene3D; 3.30.420.390; -; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR002297; DNA-dir_DNA_pol_A_mt.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR041336; DNApol_Exo.
DR InterPro; IPR047580; POLG_palm_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR PANTHER; PTHR10267; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10267:SF0; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF18136; DNApol_Exo; 1.
DR PRINTS; PR00867; DNAPOLG.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000240493};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 698..928
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 1007..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1067..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1067..1101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1168 AA; 131741 MW; 7657B08F032B7E74 CRC64;
MRALYSAAGQ LQRAPIASFV RLARYRGCQS ICRGAPSRWL ATLTQELESK DSKSLSLPSS
SRYNEVGVQQ LSDYIFPQIF PNGSKPPPED LVKLSVDHLK RHELYGKNTD TSGPIAFDLP
KLQGTTLDEH FYRLGIDCAG SHLQYAKEFA CANVPLKPKR WISRSGWTKY YPDGRTESVV
APNEDMLCFD TEVMWKESPY AVMACAVSPT AWYSWLSPWL LGESPDDKHL IPMGDSTKDR
IVVGHNVGYD RARILEEYSL EQTRTGFLDT MSLHVAVNGM CSQQRPTWMR HKKNREEREK
VASGDIEHGL IELLSNRSMH EEEELWVEKS SINSLRDVAK FHLNVTIDKA IRNDFGELDR
DGVLEKLDQL LEYCAADVSV THKVYQTVLP GFLEVCPHPV SFAALRHLSS VILPVNQTWN
SYIANAEATY QKLSTSVHER LESLAEKALE LKDKPEIWQN DPWMMQLDWS GQEIRMVKGK
RKGDPPRPAA RQKKPGMPKW YKDLFAKNDA PINLSLRTRI APLLLRLAWD GHPLFWSNQH
GWVFRVDPDD VSTYTAKLMS ECLFDDSDPA LRDDYKHSYF KLPHKDGPTA RCANPMAKGY
LTYFENGTLS SEYEYAKEAL QMNASCSYWM GARDRIMSQM VVYEKDLPEA EEGMAAKKDG
ENTQGFILPQ IVPMGTITRR AVENTWLTAS NAKKNRVGSE LKSMVKAPEG YCFVGADVDS
EELWIASLVG DATFKIHGGN AIGFMTLEGT KAAGTDLHSR TASILGISRN QAKIFNYGRI
YGAGLKFAAT LLRQFNPKLS EAETTEIAQR LYANTKGIKT NRKTINKRLF WRGGTESFVF
NKLEEFAEQD WARTPVLGAG ITQALMSRFV SKGSYLPSRI NWAIQSSGVD YLHLLIVSMD
YLIRRFNLDA RLAISVHDEI RYLVKNQDKY RAALALQVAN IWTRAMFAQQ VGIDDLPQSC
AFFSAVDIDH VLRKEVDMDC ITPSHPDAIP PGESLDIQTL LDMGPEAQLD PSVVPDPRFA
PKLDDISYTP RTPIMQKLQE SSGSSTHFIK AQIVSDEMEL QDIVKEIRGL TPSKPREPSK
PREPSKPREP SKPREPSKPR APPKPRAVSL KGVLPYTNRK APKGPNAPSS FPSEFDVIPL
DTPIPYSETM AFKYQGDSQW LQEQNDTS
//
